Biochemical and histopathological investigation of resveratrol, gliclazide, and losartan protective effects on renal damage in a diabetic rat model

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dc.contributor.authorEzel T.
dc.contributor.authorKocyigit Y.
dc.contributor.authorDeveci E.
dc.contributor.authorAtamer Y.
dc.contributor.authorSermet A.
dc.contributor.authorUysal E.
dc.contributor.authorAktaş A.
dc.date.accessioned2024-04-24T18:46:04Z
dc.date.available2024-04-24T18:46:04Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To compare the protective effects of resveratrol, gliclazide, and losartan, at biochemical and histopathological levels, on the rat kidney with experimentally induced type 1 diabetes. STUDY DESIGN: A total of 35 adult male Wistar rats were divided into control, diabetic, diabetic gliclazide, diabetic resveratrol, and diabetic losartan groups. For biochemical analysis, based on one of the kidneys, superoxide dismutase, malondialdehyde, and catalase were used for measurement. The other kidney was stained for histochemical and immunohistochemical markers and examined by light microscopy. RESULTS: Nephropathy due to diabetes was developed at the end of the third week in the diabetic group: in the glomeruli, contraction from Bowman distance, diffuse mesangial matrix increasing and tubular dilation, and cytoplasmic vacuolar changes were observed. In tubulointerstitial areas, some tubular structures, an increased expression of VEGF was observed. CONCLUSION: As a result, in diabetic rats, the effects of gliclazide, resveratrol, and losartan cure were equivalent to each other according to the parameters which were followed. Resveratrol, gliclazide, and losartan significantly protected renal glomeruli and the proximal and distal tubules. © Science Printers and Publishers, Inc.en_US
dc.identifier.endpage198en_US
dc.identifier.issn0884-6812
dc.identifier.issue3en_US
dc.identifier.pmid26173356
dc.identifier.scopus2-s2.0-84932187856
dc.identifier.scopusqualityN/A
dc.identifier.startpage187en_US
dc.identifier.urihttps://hdl.handle.net/11468/25046
dc.identifier.volume37en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherScience Printers and Publishers Inc.en_US
dc.relation.ispartofAnalytical and Quantitative Cytology and Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesis İnhibitorsen_US
dc.subjectAntihypertensive Agentsen_US
dc.subjectDiabetes Complicationsen_US
dc.subjectDiabetes İnsipidus, Nephrogenicen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectDiabetic Kidney Diseaseen_US
dc.subjectDiabetic Nephropathyen_US
dc.subjectGliclazideen_US
dc.subjectHypoglycemic Agentsen_US
dc.subjectLosartanen_US
dc.subjectResveratrolen_US
dc.titleBiochemical and histopathological investigation of resveratrol, gliclazide, and losartan protective effects on renal damage in a diabetic rat modelen_US
dc.titleBiochemical and histopathological investigation of resveratrol, gliclazide, and losartan protective effects on renal damage in a diabetic rat model
dc.typeArticleen_US

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