Biochemical and histopathological investigation of resveratrol, gliclazide, and losartan protective effects on renal damage in a diabetic rat model
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Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Science Printers and Publishers Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: To compare the protective effects of resveratrol, gliclazide, and losartan, at biochemical and histopathological levels, on the rat kidney with experimentally induced type 1 diabetes. STUDY DESIGN: A total of 35 adult male Wistar rats were divided into control, diabetic, diabetic gliclazide, diabetic resveratrol, and diabetic losartan groups. For biochemical analysis, based on one of the kidneys, superoxide dismutase, malondialdehyde, and catalase were used for measurement. The other kidney was stained for histochemical and immunohistochemical markers and examined by light microscopy. RESULTS: Nephropathy due to diabetes was developed at the end of the third week in the diabetic group: in the glomeruli, contraction from Bowman distance, diffuse mesangial matrix increasing and tubular dilation, and cytoplasmic vacuolar changes were observed. In tubulointerstitial areas, some tubular structures, an increased expression of VEGF was observed. CONCLUSION: As a result, in diabetic rats, the effects of gliclazide, resveratrol, and losartan cure were equivalent to each other according to the parameters which were followed. Resveratrol, gliclazide, and losartan significantly protected renal glomeruli and the proximal and distal tubules. © Science Printers and Publishers, Inc.
Açıklama
Anahtar Kelimeler
Angiogenesis İnhibitors, Antihypertensive Agents, Diabetes Complications, Diabetes İnsipidus, Nephrogenic, Diabetes Mellitus, Diabetic Kidney Disease, Diabetic Nephropathy, Gliclazide, Hypoglycemic Agents, Losartan, Resveratrol
Kaynak
Analytical and Quantitative Cytology and Histology
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
37
Sayı
3
