Insulin sensitivity and hyperprolactinemia

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dc.contributor.authorTuzcu, A
dc.contributor.authorBahceci, M
dc.contributor.authorDursun, M
dc.contributor.authorTurgut, C
dc.contributor.authorBahceci, S
dc.date.accessioned2024-04-24T15:59:41Z
dc.date.available2024-04-24T15:59:41Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractIt has been shown that prolactin (PRL) induces glucose intolerance, hyperinsulinemia and insulin resistance in several animal species. In women with microprolactinomas, the sensitivity to insulin is lower in hyperprolactinemia than in normoprolactinemia. Thirty non-obese women with hyperprolactinemia and 30 healthy non-obese women were included into the study. Age, body weight (bw), height, body mass index (BMI), waist circumference, hip circumference and waist to hip ratio of both patients with hyperprolactinemia and control subjects were not different. Mean serum prolactin level was higher in hyperprolactinemic patients than in control group (84.5 +/- 51.1 ng/ml and 13.8 +/- 5.3 ng/ml respectively, p<0.002). Mean HOMA-(%B) index of hyperprolactinemic patients was higher than in control subjects (121 +/- 49 and 84 +/- 38, respectively, p<0.02). Mean HOMA-(%S) index was lower in hyperprolactinemic patients (56 39 and 105 55, respectively, p<0.006). Serum total testosterone, free testosterone, androstenedione, estradiol, cortisol, sex hormone binding globulin and DHEA-S levels in both hyperprolactinemic women and healthy subjects, statistically did not show any difference between the two groups. The present data indicate that hyperprolactinemia is associated with an insulin-resistant state. This resistant state may not be a result of obesity, androgenic hormones, and SHBG or pregnancy. It may be the result of serum free fatty acids (FFA) levels, decrement in the number of insulin receptors (by a down-regulation of insulin receptors) or post-binding defect in insulin action or more. (C) 2003, Eclitrice Kurtis.en_US
dc.identifier.doi10.1007/BF03345182
dc.identifier.endpage346en_US
dc.identifier.issn0391-4097
dc.identifier.issue4en_US
dc.identifier.pmid12841542
dc.identifier.scopus2-s2.0-0038507350
dc.identifier.scopusqualityQ1
dc.identifier.startpage341en_US
dc.identifier.urihttps://doi.org/10.1007/BF03345182
dc.identifier.urihttps://hdl.handle.net/11468/14207
dc.identifier.volume26en_US
dc.identifier.wosWOS:000183517100011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEditrice Kurtis S R Len_US
dc.relation.ispartofJournal of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHyperprolactinemiaen_US
dc.subjectInsulin Resistanceen_US
dc.subjectHomaen_US
dc.subjectAndrogenic Hormones And Obesityen_US
dc.titleInsulin sensitivity and hyperprolactinemiaen_US
dc.titleInsulin sensitivity and hyperprolactinemia
dc.typeArticleen_US

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