Bacterial agents causing meningitis during 2013-2014 in Turkey: A multi-center hospital-based prospective surveillance study

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dc.contributor.authorCeyhan, Mehmet
dc.contributor.authorOzsurekci, Yasemin
dc.contributor.authorGurler, Nezahat
dc.contributor.authorOncel, Eda Karadag
dc.contributor.authorCamcioglu, Yildiz
dc.contributor.authorSalman, Nuran
dc.contributor.authorCelik, Melda
dc.date.accessioned2024-04-24T17:07:54Z
dc.date.available2024-04-24T17:07:54Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis is an observational epidemiological study to describe causes of bacterial meningitis among persons between 1 month and 18 y of age who are hospitalized with suspected bacterial meningitis in 7 Turkish regions. covering 32% of the entire population of Turkey. We present here the results from 2013 and 2014. A clinical case with meningitis was defined according to followings: any sign of meningitis including fever, vomiting, headache, and meningeal irritation in children above one year of age and fever without any documented source, impaired consciousness, prostration and seizures in those < 1 y of age. Single tube multiplex PCR assay was performed for the simultaneous identification of bacterial agents. The specific gene targets were ctrA, bex, and ply for N. meningitidis, Hib, and S. pneumoniae, respectively. PCR positive samples were recorded as laboratory-confirmed acute bacterial meningitis. A total of 665 children were hospitalized for suspected acute meningitis. The annual incidences of acute laboratory-confirmed bacterial meningitis were 0.3 cases / 100,000 population in 2013 and 0.9 cases/100,000 in 2014. Of the 94 diagnosed cases of bacterial meningitis by PCR, 85 (90.4%) were meningococcal and 9 (9.6%) were pneumococcal. Hib was not detected in any of the patients. Among meningococcal meningitis, cases of serogroup Y, A, B and W-135 were 2.4% (n = 2), 3.5% (n = 3), 32.9% (n = 28), and 42.4% (n = 36). No serogroup C was detected among meningococcal cases. Successful vaccination policies for protection from bacterial meningitis are dependent on accurate determination of the etiology of bacterial meningitis. Additionally, the epidemiology of meningococcal disease is dynamic and close monitoring of serogroup distribution is comprehensively needed to assess the benefit of adding meningococcal vaccines to the routine immunization program.en_US
dc.description.sponsorshipGlaxoSmithKline Biologicals SAen_US
dc.description.sponsorshipFunding for this study was provided by GlaxoSmithKline Biologicals SA. GlaxoSmithKline Biologicals SA was provided the opportunity to review a preliminary version of this manuscript for factual accuracy but the authors are solely responsible for final content and interpretation. The authors received no financial support or other form of compensation related to the development of the manuscript.en_US
dc.identifier.doi10.1080/21645515.2016.1209278
dc.identifier.endpage2945en_US
dc.identifier.issn2164-5515
dc.identifier.issn2164-554X
dc.identifier.issue11en_US
dc.identifier.pmid27454468
dc.identifier.scopus2-s2.0-84980335762
dc.identifier.scopusqualityQ1
dc.identifier.startpage2940en_US
dc.identifier.urihttps://doi.org/10.1080/21645515.2016.1209278
dc.identifier.urihttps://hdl.handle.net/11468/17079
dc.identifier.volume12en_US
dc.identifier.wosWOS:000388736900040
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofHuman Vaccines & Immunotherapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpidemiologyen_US
dc.subjectEtiologic Agentsen_US
dc.subjectHospital Surveillanceen_US
dc.subjectMeningitisen_US
dc.subjectTurkeyen_US
dc.titleBacterial agents causing meningitis during 2013-2014 in Turkey: A multi-center hospital-based prospective surveillance studyen_US
dc.titleBacterial agents causing meningitis during 2013-2014 in Turkey: A multi-center hospital-based prospective surveillance study
dc.typeArticleen_US

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