Partial Thrombus Resolution With Trofiban in a Pregnant Woman With Mechanical Prosthetic Mitral Valve Thrombosis

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dc.contributor.authorAkcay, Adnan Burak
dc.contributor.authorYuce, Murat
dc.contributor.authorAkcay, Murat
dc.contributor.authorSen, Nihat
dc.contributor.authorSoydinc, Hatice Ender
dc.contributor.authorDavutoglu, Vedat
dc.date.accessioned2024-04-24T17:14:38Z
dc.date.available2024-04-24T17:14:38Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe present a 15-week pregnant woman who developed mechanical mitral valve thrombosis on a fixed dose of enoxaparin therapy 60 mg twice daily. No reductions were observed in the thrombus size or mean mitral gradient on transesophageal echocardiography (TEE) with 1 week of unfractioned heparin therapy. As the thrombus on TEE imaging was hypermobile and fragile, in addition to a higher dose of enoxaparin (80 mg twice daily), trofiban infusion 0.20 mu g/kg per minute was administered for another 1 week. The thrombus on the valve was reduced in size, mobility and fragility of the thrombus diminished, and mean valve gradient decreased on TEE. As complete thrombus resolution was not observed and limitation of valve mobility continued, tissue plasminogen activator (tPA) was given to the patient. A complete thrombus resolution was observed on this therapy. The patient is presented for being the first case in literature whose valvular thrombus reduced with trofiban therapy.en_US
dc.identifier.doi10.1177/1076029610375422
dc.identifier.endpage479en_US
dc.identifier.issn1076-0296
dc.identifier.issn1938-2723
dc.identifier.issue5en_US
dc.identifier.pmid20713485
dc.identifier.scopus2-s2.0-80053613785
dc.identifier.scopusqualityQ2
dc.identifier.startpage476en_US
dc.identifier.urihttps://doi.org/10.1177/1076029610375422
dc.identifier.urihttps://hdl.handle.net/11468/18111
dc.identifier.volume17en_US
dc.identifier.wosWOS:000295613900006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofClinical and Applied Thrombosis-Hemostasis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPregnancyen_US
dc.subjectProsthetic Valveen_US
dc.subjectThrombosisen_US
dc.subjectTrofibanen_US
dc.titlePartial Thrombus Resolution With Trofiban in a Pregnant Woman With Mechanical Prosthetic Mitral Valve Thrombosisen_US
dc.titlePartial Thrombus Resolution With Trofiban in a Pregnant Woman With Mechanical Prosthetic Mitral Valve Thrombosis
dc.typeArticleen_US

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