Evaluating the effect of jointly administering synthetic graft and ankaferd blood stopper for bone recovery in created bone deformities in diabetic rats

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dc.authorid0000-0002-4430-2196en_US
dc.authorid0000-0001-6976-2589en_US
dc.authorid0000-0002-5721-8778en_US
dc.contributor.authorTanık, Abdulsamet
dc.contributor.authorDoğru, Arzum Güler
dc.contributor.authorGül, Mehmet
dc.date.accessioned2024-01-22T10:45:07Z
dc.date.available2024-01-22T10:45:07Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Bölümüen_US
dc.description.abstractObjective: In the present paper, it was purposed to examine the late impacts of bone tissue recoveries in combination with synthetic grafts and Ankaferd Blood Stopper (ABS), which are effective in bone wound healing in diabetic rats. Methods: A total of 64 Wistar albino male rats with diabetes were studied. A bone deformity was generated in the calvarium of diabetic rats. These diabetic rats are divided into 4 different groups. Only saline was applied to the bone defect in group 1, Beta-tricalcium phosphate (β-TCP) graft was administered to Group 2, ABS solution to Group 3, (β-TCP+ABS) were administered to group 4. Eight rats from each group were sacrificed on the 28th day and another 8 rats on the 56th day. Immunohistochemical, histopathological, and Dual Energy X-ray Absorptiometry (DEXA) analyzes of the obtained samples were made. Results: In histopathological measurements, osteoblastic activity and bone regeneration were considerably higher in the group treated with group 2 and group 4 when compared to the control group on the 28th and 56th day (p˂ .05). Western blotting findings showed that the osteopontin (OP) and osteonectin (ON) expression at 28th day increased dramatically in the treated with group 4. DEXA analyzes revealed that BMC values in groups treated with group 2, group 3 and group 4 on 28th day were considerably higher than the control group (p˂ .05). Conclusion: We can believe and conclude that ABS in combination with a β-TCP bone graft will produce more successful outcomes on wound healing and formation of new bone in diabetic rats.en_US
dc.identifier.citationTanık, A., Doğru, A. G. ve Gül, M. (2023). Evaluating the effect of jointly administering synthetic graft and ankaferd blood stopper for bone recovery in created bone deformities in diabetic rats. Clinical and Experimental Health Sciences, 13(2), 308-315.en_US
dc.identifier.doi10.33808/clinexphealthsci.1080508
dc.identifier.endpage315en_US
dc.identifier.issn2459-1459
dc.identifier.issue2en_US
dc.identifier.startpage308en_US
dc.identifier.trdizinid1190743
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1190743
dc.identifier.urihttps://hdl.handle.net/11468/13240
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1190743
dc.identifier.volume13en_US
dc.identifier.wosWOS:001018991100012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorDoğru, Arzum Güler
dc.language.isoenen_US
dc.publisherMarmara Üniversitesi Sağlık Bilimleri Enstitüsüen_US
dc.relation.ispartofClinical and Experimental Health Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone regenerationen_US
dc.subjectBeta-tricalcium phosphateen_US
dc.subjectDual-energy x-ray absorptiometryen_US
dc.titleEvaluating the effect of jointly administering synthetic graft and ankaferd blood stopper for bone recovery in created bone deformities in diabetic ratsen_US
dc.titleEvaluating the effect of jointly administering synthetic graft and ankaferd blood stopper for bone recovery in created bone deformities in diabetic rats
dc.typeArticleen_US

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