Diagnostic role of inflammatory markers in pediatric Brucella arthritis

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dc.contributor.authorAktar, Fesih
dc.contributor.authorTekin, Recep
dc.contributor.authorBektas, Mehmet Selcuk
dc.contributor.authorGunes, Ali
dc.contributor.authorKosker, Muhammet
dc.contributor.authorErtugrul, Sabahattin
dc.contributor.authorYilmaz, Kamil
dc.date.accessioned2024-04-24T17:14:55Z
dc.date.available2024-04-24T17:14:55Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: As a multisystem infectious disease, there is an inflammation, which causes increase in acute phase reactants in brucellosis. The mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been identified as markers of inflammation. The present study aimed to evaluate diagnostic values of these biomarkers in brucella arthritis (BA). Methods: The study included 64 children with BA and 66 healthy control subjects. Demographic features, joint involvement, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and hematological variables were retrospectively recorded. In addition, results of synovial fluid and serum tube agglutination test for brucella together with treatment regimens were recorded. Results: The mean age of the patients (53.1 % male) was 92.3 +/- 41.2 months. The most commonly affected joint was ankle (53.1 %). Synovial fluid puncture-brucella agglutination test was positive in 22 (34.3 %) patients. Puncture culture was positive in 9 patients. Most of the patients (57.8 %) were treated with a combination of rifampicin plus sulfamethoxazole/trimethoprim and gentamicin. Significantly higher mean PDW, RDW, MPV, NLR and PLR values were found in children with BA compared to control subjects (p < 0.05). A positive correlation was found between MPV and NLR values (R-2 = 0.192, p < 0.001). Conclusion: Our findings indicated that NLR and PLR are indirect markers of inflammation that may be observed abnormally increased in children with brucella arthritis. Further longitudinal studies are needed to investigate this topic to establish the more clear associations.en_US
dc.identifier.doi10.1186/s13052-016-0211-5
dc.identifier.issn1720-8424
dc.identifier.issn1824-7288
dc.identifier.pmid26753565
dc.identifier.scopus2-s2.0-84954174820
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s13052-016-0211-5
dc.identifier.urihttps://hdl.handle.net/11468/18258
dc.identifier.volume42en_US
dc.identifier.wosWOS:000368797500002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofItalian Journal of Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrucella Arthritisen_US
dc.subjectChilden_US
dc.subjectCorrelationen_US
dc.subjectInflammatory Markersen_US
dc.subjectDiagnostic Roleen_US
dc.titleDiagnostic role of inflammatory markers in pediatric Brucella arthritisen_US
dc.titleDiagnostic role of inflammatory markers in pediatric Brucella arthritis
dc.typeArticleen_US

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