Comparison of Mitomycin C and Limbal-Conjunctival Autograft in the Prevention of Pterygial Recurrence in Turkish Patients: A One-Year, Randomized, Assessor-Masked, Controlled Trial

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dc.contributor.authorAri, Seyhmus
dc.contributor.authorCaca, Ihsan
dc.contributor.authorYildiz, Zennure Oezdemir
dc.contributor.authorSakalar, Yildirim Bayezit
dc.contributor.authorDogan, Eyuep
dc.date.accessioned2024-04-24T16:11:14Z
dc.date.available2024-04-24T16:11:14Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: A pterygium is a fibrovascular overgrowth of degenerative bulbar conjunctival tissue that grows over the limbus onto the cornea. Although various approaches have been proposed for the treatment of pterygium, the common problem after these treatments is recurrence. OBJECTIVES: The goals of this study were to compare the efficacy of mitomycin C (MMC) and limbal-conjunctival autograft (LCAU) in preventing recurrence of primary pterygia and to monitor long-term adverse effects (AEs). METHODS: Patients undergoing pterygium surgery between February 2006 and May 2007 were assessed prospectively and randomly divided into 2 groups using a random number table. The MMC group underwent pterygium excision and received 0.02%, MMC intraoperatively for 2 minutes. The LCAU group under-went pterygium excision and LCAU. Recurrence and AE rates of the 2 treatments were compared during the 1-year follow-up period. Assessors for pterygial recurrence were masked to treatment group. RESULTS: One hundred thirteen eyes (57 patients in the MMC group and 56 patients in the LCAU group) were included in the study. Thirteen of the patients (7 in the MMC group and 6 in the LCAU group) were withdrawn due to irregular attendance at follow-up visits or lack of sufficient dose and duration for postoperative topical antibiotic and steroid administration; their data were excluded from analysis. Fifty patients (MMC group: 26 men, 24 women; mean [SD] age, 48.0 [12.3] years; age range, 30-73 years; LCAU group: 27 men, 23 women; mean age, 49.0 [12.6] years; age range, 28-71 years) in each group completed the study. The mean (SD) length of the pterygium across the limbus was similar in the MMC group and the LCAU group (4.18 [1.27] vs 4.07 [1.24] mm). The mean follow-up period was also similar in the 2 groups (16.0 [1.9] vs 15.0 [1.7] months). The rate of recurrence was significantly greater in the MMC group than in the LCAU group (10 [20.0%] vs 2 [4.0%] patients; P = 0.035). Seven patients (14.0%) In the MMC group experienced AEs: conjunctival cyst (3 patients), symblepharon (2), conjunctival granuloma (1), and dellen (1). In the LCAU group, 1 patient (2.0%; P = 0.032 vs MMC group) experienced permanent graft edema. All patients in the LCAU group experienced transient graft edema, with recovery occurring in 3 to 4 weeks. There were no intraoperative complications and there was no graft rejection. CONCLUSIONS: Recurrence and postoperative AEs were less frequently observed in primary excision with LCAU than with MMC in these Turkish patients who completed the study. This study found that pterygium excision with LCAU was well tolerated and effective in these patients. (Curr Ther Res Clin Exp. 2009;70:274-281) (C) 2009 Excerpta Medica Inc.en_US
dc.identifier.doi10.1016/j.curtheres.2009.08.004
dc.identifier.endpage281en_US
dc.identifier.issn0011-393X
dc.identifier.issue4en_US
dc.identifier.pmid24683237
dc.identifier.scopus2-s2.0-70249128641
dc.identifier.scopusqualityQ3
dc.identifier.startpage274en_US
dc.identifier.urihttps://doi.org/10.1016/j.curtheres.2009.08.004
dc.identifier.urihttps://hdl.handle.net/11468/15323
dc.identifier.volume70en_US
dc.identifier.wosWOS:000270108200002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical and Experimental
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMitomycin Cen_US
dc.subjectLimbal-Conjunctival Autograften_US
dc.subjectPterygiumen_US
dc.titleComparison of Mitomycin C and Limbal-Conjunctival Autograft in the Prevention of Pterygial Recurrence in Turkish Patients: A One-Year, Randomized, Assessor-Masked, Controlled Trialen_US
dc.titleComparison of Mitomycin C and Limbal-Conjunctival Autograft in the Prevention of Pterygial Recurrence in Turkish Patients: A One-Year, Randomized, Assessor-Masked, Controlled Trial
dc.typeArticleen_US

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