Serum prolidase activity and oxidant-antioxidant status in children with chronic hepatitis B virus infection

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dc.contributor.authorSen, Velat
dc.contributor.authorUluca, Unal
dc.contributor.authorEce, Aydin
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorBozkurt, Fatma
dc.contributor.authorAktar, Fesih
dc.contributor.authorBagli, Sedat
dc.date.accessioned2024-04-24T17:14:55Z
dc.date.available2024-04-24T17:14:55Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Chronic hepatitis B (CHB) is a global health problem that can result in serious complications associated with collagen degradation. Prolidase is a specific imidodipeptidase that plays an important role in the breakdown of collagen. The aim of this study was to investigate prolidase activity and oxidant-antioxidant status in children with CHB. Methods: This prospective case control study includes 38 patients with CHB, 31 patients with inactive hepatitis B (IHB), and 29 healthy matched control subjects. Serum prolidase enzyme activity (SPEA), total antioxidant capacity (TAC), total oxidative activity (TOA), and malondialdehyde (MDA) level were measured and oxidative stress index (OSI) was calculated for each group. Results: Patients with CHB had significantly higher SPEA levels (207.82 +/- 186.80 IU/L) than did the controls (58.6 +/- 38.1 IU/L) and IHB patients (67.1 +/- 39.9) (p < 0.001). CHB patients also had significantly higher TOA (45.0 +/- 19.9 vs. 29.4 +/- 11.7 (mu molH(2)O(2) Eq./L), p = 0.005), OSI (33.1 +/- 21.4 vs. 17.5 +/- 10.2, p = 0.002) and MDA (13.4 +/- 4.0 vs. 7.8 +/- 2.6 mu m/L, p < 0.001) values compared with the controls. TOA (32.0 +/- 10.0) and OSI (15.4 +/- 11.0) values of IHB patients were significantly lower than those of CHB patients (p < 0.05). SPEA had significant correlations with HBV-DNA and ALT values (r = 0.514 and r = 0.454, p < 0.001). Conclusion: Our results suggest that prolidase activity can be considered as a reliable marker for CHB and increased oxidative stress appears to be related to chronicity of the disease.en_US
dc.identifier.citationŞen, V., Uluca, Ü., Ece, A., Kaplan, İ., Bozkurt, F., Aktar, F. ve diğerleri. (2024). Serum prolidase activity and oxidant-antioxidant status in children with chronic hepatitis B virus infection. Italian Journal of Pediatrics, 40(95), 1-8.
dc.identifier.doi10.1186/s13052-014-0095-1
dc.identifier.issn1720-8424
dc.identifier.issn1824-7288
dc.identifier.pmid25425101
dc.identifier.scopus2-s2.0-85017330261
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s13052-014-0095-1
dc.identifier.urihttps://hdl.handle.net/11468/18255
dc.identifier.volume40en_US
dc.identifier.wosWOS:000349346900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofItalian Journal of Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic Hepatitis Ben_US
dc.subjectProlidaseen_US
dc.subjectOxidative Stressen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.titleSerum prolidase activity and oxidant-antioxidant status in children with chronic hepatitis B virus infectionen_US
dc.titleSerum prolidase activity and oxidant-antioxidant status in children with chronic hepatitis B virus infection
dc.typeArticleen_US

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