Effectiveness of boric acid in preventing acrylamide-conducted brain damage in rats

Basit Öğe Kaydı
dc.authorid0000-0002-5648-6498en_US
dc.authorid0000-0001-9843-6301en_US
dc.authorid0000-0003-1249-6958en_US
dc.authorid0000-0002-1659-1189en_US
dc.authorid0000-0001-7203-2288en_US
dc.contributor.authorYıldızhan, Eda
dc.contributor.authorÜlger, Burak Veli
dc.contributor.authorGündüz, Ercan
dc.contributor.authorAkkuş, Murat
dc.contributor.authorBilge, Hüseyin
dc.date.accessioned2023-11-30T06:19:25Z
dc.date.available2023-11-30T06:19:25Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractAim: Acrylamide (ACR) is a water-soluble neurotoxic substance that has been widely researched in recent years. Boric acid (BA) is a component that does not have a toxic effect when taken at low concentrations and has a cystotoxic activity. Studies have reported that BA has antioxidant effects. In this study, we aimed to examine the protective efficacy of BA against the toxic damage that ACR may cause in the brain tissue. Methods: In this study, 28 Wistar Albino male rats with an average weight of 320-400 grams were used. In our study, ACR was administered intraperitoneally (i.p.) at a dose of 50 mg/kg for 14 days, while BA was administered orally (p.o.) with a dose of 200 mg/kg for 14 days. Group 1 (n=7): It is the control group and no medication was administered for 14 days. Group 2 (n=7): ACR group, Group 3 (n=7): BA group and Group 4 (n=7): ACR + BA group. Results: The comparison between the groups in terms of serum Total Oxidant Status (TOS) and Malondialdehyde (MDA) analysis revealed that the highest MDA level was in the ACR group. The MDA and TOS levels of the ACR+BA group were significantly lower than the ACR group (p<0.05). Conclusions: Our study revealed that BA has a protective effect in the prevention of neurotoxicity due to oxidative stress after ACR applicationen_US
dc.identifier.citationYıldızhan, E., Ülger, B. V., Gündüz, E., Akkuş, M. ve Bilge, H. (2023). Effectiveness of boric acid in preventing acrylamide-conducted brain damage in rats. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, 6(1), 92-97.en_US
dc.identifier.doi10.36516/jocass.1239256
dc.identifier.endpage97en_US
dc.identifier.issn2667-498X
dc.identifier.issue1en_US
dc.identifier.startpage92en_US
dc.identifier.trdizinid1174942
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1174942
dc.identifier.urihttps://hdl.handle.net/11468/13067
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1174942
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorYıldızhan, Eda
dc.institutionauthorÜlger, Burak Veli
dc.institutionauthorGündüz, Ercan
dc.institutionauthorAkkuş, Murat
dc.language.isoenen_US
dc.publisherMerthan Tunayen_US
dc.relation.ispartofÇukurova Anestezi ve Cerrahi Bilimler Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcrylamideen_US
dc.subjectBoric aciden_US
dc.subjectOxidative stressen_US
dc.titleEffectiveness of boric acid in preventing acrylamide-conducted brain damage in ratsen_US
dc.titleEffectiveness of boric acid in preventing acrylamide-conducted brain damage in rats
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Effectiveness of Boric Acid in Preventing Acrylamide-Conducted Brain Damage in Rats.pdf
Boyut:
1.07 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Temel Tıp Bilimleri Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu