Effectiveness of boric acid in preventing acrylamide-conducted brain damage in rats
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Merthan Tunay
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Acrylamide (ACR) is a water-soluble neurotoxic substance that has been widely researched in
recent years. Boric acid (BA) is a component that does not have a toxic effect when taken at low
concentrations and has a cystotoxic activity. Studies have reported that BA has antioxidant effects.
In this study, we aimed to examine the protective efficacy of BA against the toxic damage that ACR
may cause in the brain tissue.
Methods: In this study, 28 Wistar Albino male rats with an average weight of 320-400 grams were
used. In our study, ACR was administered intraperitoneally (i.p.) at a dose of 50 mg/kg for 14 days,
while BA was administered orally (p.o.) with a dose of 200 mg/kg for 14 days. Group 1 (n=7): It is
the control group and no medication was administered for 14 days. Group 2 (n=7): ACR group,
Group 3 (n=7): BA group and Group 4 (n=7): ACR + BA group.
Results: The comparison between the groups in terms of serum Total Oxidant Status (TOS) and
Malondialdehyde (MDA) analysis revealed that the highest MDA level was in the ACR group. The
MDA and TOS levels of the ACR+BA group were significantly lower than the ACR group (p<0.05).
Conclusions: Our study revealed that BA has a protective effect in the prevention of neurotoxicity
due to oxidative stress after ACR application
Açıklama
Anahtar Kelimeler
Acrylamide, Boric acid, Oxidative stress
Kaynak
Çukurova Anestezi ve Cerrahi Bilimler Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
6
Sayı
1
Künye
Yıldızhan, E., Ülger, B. V., Gündüz, E., Akkuş, M. ve Bilge, H. (2023). Effectiveness of boric acid in preventing acrylamide-conducted brain damage in rats. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, 6(1), 92-97.
