Evaluation of paraoxonase, malondialdehyde, and lipoprotein levels in patients with asymptomatic cholelithiasis

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dc.contributor.authorAtamer, Aytac
dc.contributor.authorKurdas-Ovunc, Ayse O.
dc.contributor.authorYesil, Atakan
dc.contributor.authorAtamer, Yildiz
dc.date.accessioned2024-04-24T17:24:14Z
dc.date.available2024-04-24T17:24:14Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground/Aim: To compare lipoprotein and malondialdehyde levels and paraoxonase-1 activity between subjects with asymptomatic cholelithiasis and controls. Patients and Methods: Eighty subjects with asymptomatic cholelithiasis (55 women, 25 men, mean age: 51, SD 14 years) and 40 control subjects without cholelithiasis (25 women, 25 men, mean age: 51, SD 12 years) were enrolled to the study. Serum paraoxonase activity, lipoproteins, and malondialdehyde were measured. Results: In the cholelithiasis group, serum total cholesterol, low-density lipoprotein cholesterol, and malondialdehyde were significantly higher and high-density lipoprotein cholesterol (HDL-C) and paraoxonase-1 were significantly lower than the controls. In cholelithiasis patients with serum glucose level > 100 mg/dL, body mass index, serum total cholesterol, triglyceride (TG), and malondialdehyde levels were significantly higher than cholelithiasis patients with serum glucose level < 100 mg/dL. Paraoxonase-1 activity was significantly lower in patients with serum glucose level > 100 mg/dL. In cholelithiasis patients with TG > 150 mg/dL, mean age, body mass index, glucose, total cholesterol, and malondialdehyde were significantly higher than in cholelithiasis patients with TG < 150 mg/dL. In cholelithiasis subgroup with TG > 150 mg/dL, HDL-C level and paraoxonase-1 activity were lower than in the cholelithiasis subgroup with TG < 150 mg/dL. All of the above comparisons were statistically significant (P < 0.05). Conclusions: Patients with asymptomatic cholelithiasis have evidence of increased lipid peroxidation and decreased antioxidant capacity. Patients with asymptomatic cholelithiasis with components of the metabolic syndrome have more lipid peroxidation and less antioxidant capacity than patients with asymptomatic cholelithiasis but without the components of the metabolic syndrome.en_US
dc.identifier.doi10.4103/1319-3767.126325
dc.identifier.endpage73en_US
dc.identifier.issn1319-3767
dc.identifier.issn1998-4049
dc.identifier.issue1en_US
dc.identifier.pmid24496161
dc.identifier.scopus2-s2.0-84894120583
dc.identifier.scopusqualityQ2
dc.identifier.startpage66en_US
dc.identifier.urihttps://doi.org/10.4103/1319-3767.126325
dc.identifier.urihttps://hdl.handle.net/11468/19543
dc.identifier.volume20en_US
dc.identifier.wosWOS:000331702000009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofSaudi Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCholelithiasisen_US
dc.subjectLipoproteinsen_US
dc.subjectMalondialdehydeen_US
dc.subjectParaoxonaseen_US
dc.titleEvaluation of paraoxonase, malondialdehyde, and lipoprotein levels in patients with asymptomatic cholelithiasisen_US
dc.titleEvaluation of paraoxonase, malondialdehyde, and lipoprotein levels in patients with asymptomatic cholelithiasis
dc.typeArticleen_US

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