The effects of ellagic acid on experimental corrosive esophageal burn injury

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dc.authorid0000-0002-6384-9146en_US
dc.authorid0000-0003-4902-4022en_US
dc.contributor.authorKeşim, Dilek Aygün
dc.contributor.authorAşır, Fırat
dc.contributor.authorAyaz, Hayat
dc.contributor.authorKorak, Tuğcan
dc.date.accessioned2024-04-18T11:34:37Z
dc.date.available2024-04-18T11:34:37Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractThis study aimed to investigate the antioxidant effect of Ellagic acid (EA) on wound healing in sodium hydroxide (NaOH)-induced corrosive esophageal burn injury. The interaction networks and functional annotations were conducted using Cytoscape software. A total of 24 Wistar albino rats were divided into control, corrosive esophageal burn (CEB) and CEB + EA groups. Burn injury was created by 20% NaOH and 30 mg/kg EA was per oral administered to rats. At the end of the 28-day experimental period, Malondialdehyde (MDA) content was measured. Esophageal tissue samples were processed for histological staining. The EA–target interaction network was revealed to be involved in regulating crucial cellular mechanisms for burn wound healing, with epidermal growth factor (EGF) identified as a central mediator. An increase in animal weight in the CEB + EA group was observed in the EA-treated group after CEB injury. Burn injury increased MDA content, but EA treatment decreased its level after CEB injury. Stenosis index, collagen degeneration, inflammation, fibrosis and necrosis levels were increased after CEB injury. EA treatment improved histopathology in the CEB + EA group compared to the CEB group. The expression of EGF was decreased in the CEB group but upregulated in the EA-treated group, suggesting a potential involvement of EA in cellular processes and tissue regeneration. EA, through its antioxidative and tissue regenerative properties, significantly contributes to alleviating the adverse effects of CEB injury, promoting wound healing.en_US
dc.identifier.citationKeşim, D. A., Aşır, F., Ayaz, H. ve Korak, T. (2024). The effects of ellagic acid on experimental corrosive esophageal burn injury. Current Issues in Molecular Biology, 46(2), 1579-1592.en_US
dc.identifier.doi10.3390/cimb46020102
dc.identifier.endpage1592en_US
dc.identifier.issn1467-3037
dc.identifier.issue2en_US
dc.identifier.pmid38392220
dc.identifier.scopus2-s2.0-85185892293
dc.identifier.scopusqualityQ3
dc.identifier.startpage1579en_US
dc.identifier.urihttps://www.mdpi.com/1467-3045/46/2/102
dc.identifier.urihttps://hdl.handle.net/11468/13913
dc.identifier.volume46en_US
dc.identifier.wosWOS:001168339200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKeşim, Dilek Aygün
dc.institutionauthorAşır, Fırat
dc.institutionauthorAyaz, Hayat
dc.language.isoenen_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.ispartofCurrent Issues in Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAntioxidanten_US
dc.subjectCorrosive substanceen_US
dc.subjectEllagic aciden_US
dc.subjectNaOHen_US
dc.titleThe effects of ellagic acid on experimental corrosive esophageal burn injuryen_US
dc.titleThe effects of ellagic acid on experimental corrosive esophageal burn injury
dc.typeArticleen_US

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