Detection of borderline dosage of malathion intoxication in a rat's brain

Basit Öğe Kaydı
dc.contributor.authorVarol, S.
dc.contributor.authorBasarslan, S. K.
dc.contributor.authorFirat, U.
dc.contributor.authorAlp, H.
dc.contributor.authorUzar, E.
dc.contributor.authorArikanoglu, A.
dc.contributor.authorEvliyaoglu, O.
dc.date.accessioned2024-04-24T17:33:27Z
dc.date.available2024-04-24T17:33:27Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: Humans and other animals are liable to expose to low doses of malathion (MAL). However, experimental studies on its toxic threshold dose and toxic low-dose effects have not been conducted. The aims of this study were to detect the initiation of the toxic effects of sub-acute low doses (2.5, 5, and 10 mg/kg) of MAL by immunohistochemical and biochemical parameters in rat brain. MATERIALS AND METHODS: Twenty-eight rats were randomly assigned into four groups (n=7) including control and three different amounts of MAL-exposed groups (2.5, 5, and 10 mg/kg). RESULTS: On immunohistochemical examination, the number of caspase-3-positive cells in all MAL-exposed groups was significantly higher than in the control group. Consistent with this, the total antioxidant capacity, total oxidant status, and the levels of superoxide dismutase, malondialdehyde, and paraoxanase activity were significantly different in the 5 and 10 mg/kg MAL-exposed groups compared with the control group. Additionally, the total oxidant status and malondialdehyde levels were significantly higher in the 5 and 10 mg/kg MAL-exposed groups compared with those in the 2.5 mg/kg MAL-exposed group. CONCLUSIONS: Our results indicate that over 5 mg/kg MAL exposure may result in dose-dependent oxidative stress, increased caspase-3 activity, and launching to the toxic effects in rat brain.en_US
dc.identifier.endpage2323en_US
dc.identifier.issn1128-3602
dc.identifier.issue12en_US
dc.identifier.pmid26166662
dc.identifier.scopus2-s2.0-84942280034
dc.identifier.scopusqualityQ2
dc.identifier.startpage2318en_US
dc.identifier.urihttps://hdl.handle.net/11468/20695
dc.identifier.volume19en_US
dc.identifier.wosWOS:000357991900031
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMalathionen_US
dc.subjectIts Toxic Dosageen_US
dc.subjectOxidative Stressen_US
dc.subjectRat Brainen_US
dc.titleDetection of borderline dosage of malathion intoxication in a rat's brainen_US
dc.titleDetection of borderline dosage of malathion intoxication in a rat's brain
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu