Dose-dependent effects of propofol on expression ICAM-1 in rabbit aorta endothelial cells

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dc.contributor.authorKetani, M. Aydin
dc.contributor.authorKanay, Berna Ersoez
dc.contributor.authorKetani, Sennur
dc.contributor.authorUnver, Ozkan
dc.contributor.authorKilinc, Mehmet
dc.date.accessioned2024-04-24T17:33:31Z
dc.date.available2024-04-24T17:33:31Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe dose-dependent effects of propofol on expression intracellular adhesion molecule (ICAM-1) in rabbit aorta endothelial cells was examined. Twenty adult New Zeland albino rabbits were used in this study. One control and three experimantal groups were designed. In experimantal groups; for group I propofol was not applied, group II 0.5, group III 4.0 and group IV 8.0 mg/kg propofol were applied to rabbits by marginal ear vein. One hour after applying propofol, control and experimantal group rabbits were sacrificed and their aorta were removed. The sections were stained with APAAP immunohistochemical staining for evaluation using a light microscope. This marked ICAM-1 immunoreactivity was maintained in 8.0 mg/kg of propofol applied to rabbits of aorta endothelium, whereas mild stain was observed for other experimantal groups. The present study indicated that there is parallel relationship between endothelial cells ICAM-1 expression and different doses of propofol.en_US
dc.description.sponsorshipDUAPK [DUAPK-VF-376]en_US
dc.description.sponsorshipThis study was supported by DUAPK (DUAPK-VF-376).en_US
dc.identifier.endpage6693en_US
dc.identifier.issn1684-5315
dc.identifier.issue23en_US
dc.identifier.scopus2-s2.0-74549190485
dc.identifier.scopusqualityN/A
dc.identifier.startpage6688en_US
dc.identifier.urihttps://hdl.handle.net/11468/20724
dc.identifier.volume8en_US
dc.identifier.wosWOS:000273767700032
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal of Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIcam-1en_US
dc.subjectRabbiten_US
dc.subjectAorta Endotheliumen_US
dc.subjectPropofolen_US
dc.titleDose-dependent effects of propofol on expression ICAM-1 in rabbit aorta endothelial cellsen_US
dc.titleDose-dependent effects of propofol on expression ICAM-1 in rabbit aorta endothelial cells
dc.typeArticleen_US

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