Dose-dependent effects of propofol on expression ICAM-1 in rabbit aorta endothelial cells

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Tarih

2009

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Academic Journals

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

The dose-dependent effects of propofol on expression intracellular adhesion molecule (ICAM-1) in rabbit aorta endothelial cells was examined. Twenty adult New Zeland albino rabbits were used in this study. One control and three experimantal groups were designed. In experimantal groups; for group I propofol was not applied, group II 0.5, group III 4.0 and group IV 8.0 mg/kg propofol were applied to rabbits by marginal ear vein. One hour after applying propofol, control and experimantal group rabbits were sacrificed and their aorta were removed. The sections were stained with APAAP immunohistochemical staining for evaluation using a light microscope. This marked ICAM-1 immunoreactivity was maintained in 8.0 mg/kg of propofol applied to rabbits of aorta endothelium, whereas mild stain was observed for other experimantal groups. The present study indicated that there is parallel relationship between endothelial cells ICAM-1 expression and different doses of propofol.

Açıklama

Anahtar Kelimeler

Icam-1, Rabbit, Aorta Endothelium, Propofol

Kaynak

African Journal of Biotechnology

WoS Q Değeri

Q4

Scopus Q Değeri

N/A

Cilt

8

Sayı

23

Künye