Protective effect of wolfberry extract on acetic acid-induced colitis in rats

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dc.authorid0000-0001-5005-6369en_US
dc.authorid0000-0003-1100-3613en_US
dc.contributor.authorİçer, M.
dc.contributor.authorGündüz, E.
dc.contributor.authorZengin, Y.
dc.contributor.authorDursun, R.
dc.contributor.authorDurgun, Hasan Mansur
dc.contributor.authorAlabalık, U.
dc.contributor.authorKaplan, I.
dc.contributor.authorGüloğlu, C.
dc.date.accessioned2022-12-22T06:38:56Z
dc.date.available2022-12-22T06:38:56Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalıen_US
dc.description.abstractObjective: To investigate the protective effect of wolfberry (WB) against acetic acid-induced colitis in rats. Methods: The rats were divided into four groups with eight rats in each group: the control group, WB group, colitis group and WB + colitis group. Distal colitis was induced in rats by intracolonic instillation of 4% acetic acid. Woliberry + colitis group received 100 mg/kg of WB extract dissolved in saline through the intraperitoneal route for 7 days. Acute colitis was created on the 8th day, and the rats were sacrificed 48 hours later Colonic damage was assessed by macroscopic and histological criteria as well as biochemical markers. Results: Mean total antioxidant capacity (TAC), total oxidant status (TOS), tumour necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 levels were significantly higher in the colitis group compared with the control and WB groups (p < 0.05). The WB + colitis group had significantly lower TAC, TOS, TNF-alpha, IL-1 beta and IL-6 levels compared with the colitis group (p < 0.05). The analyses of the histopathological findings indicated that the colitis group had a significantly higher histopathological damage score than the control group (3.12 +/- 0.45, 0 +/- 0.00, respectively; p < 0.05). Histopathological damage score was significantly higher in the WB + colitis group than in the control group and statistically significantly lower than the colitis group (1.62 +/- 0.44, 0 +/- 0.00, respectively; 3.12 +/- 0.45, respectively; p < 0.05 for both comparisons). Conclusion: Wolfberry extract is an agent that is effective for preventing acetic acid-induced colitis in rats.en_US
dc.identifier.citationİçer, M., Gündüz, E., Zengin, Y., Dursun, R., Durgun, H.M., Alabalık, U. ve diğerleri. (2021). Protective effect of wolfberry extract on acetic acid-induced colitis in rats. West Indian Medical Journal, 69(5), 356-361.en_US
dc.identifier.doi10.7727/wimj.2015.444
dc.identifier.endpage361en_US
dc.identifier.issn0043-3144
dc.identifier.issn2309-5830
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85122068746
dc.identifier.scopusqualityQ4
dc.identifier.startpage356en_US
dc.identifier.urihttps://www.mona.uwi.edu/fms/wimj/article/2746
dc.identifier.urihttps://hdl.handle.net/11468/11104
dc.identifier.volume69en_US
dc.identifier.wosWOS:000719641000017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorİçer, M.
dc.institutionauthorGündüz, E.
dc.institutionauthorZengin, Y.
dc.institutionauthorDursun, R.
dc.institutionauthorDurgun, Hasan Mansur
dc.institutionauthorAlabalık, U.
dc.institutionauthorKaplan, I.
dc.institutionauthorGüloğlu, C.
dc.language.isoenen_US
dc.publisherUniv West Indies Faculty Medical Sciencesen_US
dc.relation.ispartofWest Indian Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute colitisen_US
dc.subjectAntioxidanten_US
dc.subjectWolfberryen_US
dc.titleProtective effect of wolfberry extract on acetic acid-induced colitis in ratsen_US
dc.titleProtective effect of wolfberry extract on acetic acid-induced colitis in rats
dc.typeArticleen_US

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