Protective effect of wolfberry extract on acetic acid-induced colitis in rats
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ West Indies Faculty Medical Sciences
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To investigate the protective effect of wolfberry (WB) against acetic acid-induced colitis in rats.
Methods: The rats were divided into four groups with eight rats in each group: the control group, WB group, colitis group and WB + colitis group. Distal colitis was induced in rats by intracolonic instillation of 4% acetic acid. Woliberry + colitis group received 100 mg/kg of WB extract dissolved in saline through the intraperitoneal route for 7 days. Acute colitis was created on the 8th day, and the rats were sacrificed 48 hours later Colonic damage was assessed by macroscopic and histological criteria as well as biochemical markers.
Results: Mean total antioxidant capacity (TAC), total oxidant status (TOS), tumour necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 levels were significantly higher in the colitis group compared with the control and WB groups (p < 0.05). The WB + colitis group had significantly lower TAC, TOS, TNF-alpha, IL-1 beta and IL-6 levels compared with the colitis group (p < 0.05). The analyses of the histopathological findings indicated that the colitis group had a significantly higher histopathological damage score than the control group (3.12 +/- 0.45, 0 +/- 0.00, respectively; p < 0.05). Histopathological damage score was significantly higher in the WB + colitis group than in the control group and statistically significantly lower than the colitis group (1.62 +/- 0.44, 0 +/- 0.00, respectively; 3.12 +/- 0.45, respectively; p < 0.05 for both comparisons).
Conclusion: Wolfberry extract is an agent that is effective for preventing acetic acid-induced colitis in rats.
Açıklama
Anahtar Kelimeler
Acute colitis, Antioxidant, Wolfberry
Kaynak
West Indian Medical Journal
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
69
Sayı
5
Künye
İçer, M., Gündüz, E., Zengin, Y., Dursun, R., Durgun, H.M., Alabalık, U. ve diğerleri. (2021). Protective effect of wolfberry extract on acetic acid-induced colitis in rats. West Indian Medical Journal, 69(5), 356-361.
