Stromal Clues in Endometrial Carcinoma: Loss of Expression of ?-Catenin, Epithelial-Mesenchymal Transition Regulators, and Estrogen-Progesterone Receptor

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dc.contributor.authorSenol, Serkan
dc.contributor.authorSayar, Ilyas
dc.contributor.authorCeyran, Ayse B.
dc.contributor.authorIbiloglu, Ibrahim
dc.contributor.authorAkalin, Ibrahim
dc.contributor.authorFirat, Ugur
dc.contributor.authorKosemetin, Duygu
dc.date.accessioned2024-04-24T17:08:24Z
dc.date.available2024-04-24T17:08:24Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractEpithelial-stroma interactions in the endometrium are known to be responsible for physiological functions and emergence of several pathologic lesions. Periglandular stromal cells act on endometrial cells in a paracrine manner through sex hormones. In this study, we immunohistochemically evaluated the expression of epithelial-mesenchymal transition regulators (SNAIL/SLUG, TWIST, ZEB1), adhesion molecules beta-catenin and E-cadhenin), estrogen (ER)-progesterone (PR) receptor and their correlation with each other in 30 benign, 148 hyperplastic (EH), and 101 endometrioid-type endometrial carcinoma (EC) endometria. In the epithelial component, loss of expression in E-cadherin, ER and PR, and overexpression of TWIST and ZEB1 were significantly higher in EC than in EH (P<0.01). In the periglandular stromal component, beta-catenin and SNAIL/SLUG expression were significantly higher in normal endometrium and simple without atypical EH compared with complex atypical EH and EC (P < 0.01). In addition, periglandular stromal TWIST expression was significantly higher in EH group compared with EC (P<0.05). There was significantly negative correlation between beta-catenin and ER, TWIST and ER, and TWIST and PR in hyperplastic and carcinomatous glandular epithelium, whereas there was a significantly positive correlation between beta-catenin and SNAIL-SLUG, beta-catenin and TWIST, beta-catenin and ER, beta-catenin and PR, SNAIL -SLUG and ER, SNAIL SLUG and PR, TWIST and ER, TWIST and PR, in periglandular/cancer-associated stromal cells (P<0.01). In conclusion, the pattern of positive and negative correlations in the expression of epithelial-mesenchymal transition regulators (SNAIL -SLUG and TWIST), sex hormone receptors (ER and PR), and P-catenin between ECs and hyperplasia, as well as between epithelium and stroma herein, is suggestive of a significant role for these proteins and their underlying molecular processes in the development of endometrial carcinomas.en_US
dc.description.sponsorshipIstanbul Medeniyet University [TSA-2013-401]en_US
dc.description.sponsorshipSupported by the Research Fund of Istanbul Medeniyet University (Project Number: TSA-2013-401).en_US
dc.identifier.doi10.1097/PGP.0000000000000233
dc.identifier.endpage248en_US
dc.identifier.issn0277-1691
dc.identifier.issn1538-7151
dc.identifier.issue3en_US
dc.identifier.pmid26367784
dc.identifier.scopus2-s2.0-84944339798
dc.identifier.scopusqualityQ2
dc.identifier.startpage238en_US
dc.identifier.urihttps://doi.org/10.1097/PGP.0000000000000233
dc.identifier.urihttps://hdl.handle.net/11468/17330
dc.identifier.volume35en_US
dc.identifier.wosWOS:000374511200005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofInternational Journal of Gynecological Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometriumen_US
dc.subjectEmten_US
dc.subjectBeta-Cateninen_US
dc.subjectE-Cadherinen_US
dc.subjectSex Steroid Receptorsen_US
dc.titleStromal Clues in Endometrial Carcinoma: Loss of Expression of ?-Catenin, Epithelial-Mesenchymal Transition Regulators, and Estrogen-Progesterone Receptoren_US
dc.titleStromal Clues in Endometrial Carcinoma: Loss of Expression of ?-Catenin, Epithelial-Mesenchymal Transition Regulators, and Estrogen-Progesterone Receptor
dc.typeArticleen_US

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