Serum cardiac troponin T levels as an indicator of myocardial injury in ischemic and hemorrhagic stroke patients

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dc.contributor.authorApak, I
dc.contributor.authorIltumur, K
dc.contributor.authorTaman, Y
dc.contributor.authorKaya, N
dc.date.accessioned2024-04-24T17:18:12Z
dc.date.available2024-04-24T17:18:12Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractAPAK. I ILTUMUR, K., TMAM, Y. and KAYA, N. Serum Cardiac Troponin T Levels as an Indicator of myocardial Injury in Ischemic and Hemorrhagic Smoke Patients. Tohoku J. Exp. Med.. 2005, 205 (2) 93-101 - Mail), studies in the literature have clearly shown the increase in creatine kinase-myocardial subfraction (CK-MB) levels and changes in electrocardiography (ECG) after stroke. However. the studies on cardiac troponin T (cTnT) which is more sensitive and specific to myocardium after stroke are relatively Scarce. Moreover, its associations with volume of stroke lesions and type of stroke have not been investigated thoroughly. Thus, the aims of this study were to investigate a predictive value of cTnT in assessing myocardial injury and cardiac dysfunction in different types of stroke (hemorrhagic or ischemic stroke) and its relationship with stroke size and volume. This stud), included 62 patients (30 males and 32 females) with acute stroke confirmed by computed tomography (CT). Blood samples were obtained within 24 hours of stroke onset to measure the serum levels of creatin kinase (CK), CK-MB, lactate dehydrogenate (LDH), and cTnT. ECG and echocardiography were perfomed to assess myocardial function and left ventricular ejection fraction (LVEF). Of all patients included in the study. 20 patients (32%) demonstrated elevations in cTnT, while 28 patients (45%) had increased CK-MB levels. Serum levels of cTnT were positively correlated with stroke volume (r = 0.65 p < 0.0001), while inversely correlated with LVEF (r= -0.53,p<0001). Serum levels of both CK-MB and cTnT were higher in patients with hemorrhagic stroke than those with ischemic stroke but this difference was not significant (p>0.05). As a conclusion. cTnT has a higher specificity and sensitivity in detecting myocardial injury after stroke of both ischemic and hemorrhagic origins. Measurement of the serum levels of cTnT is of clinical importance in evaluating myocardial injury and provides a useful aid in estimating the volume of stroke lesions. - cardiac troponin T; creatine kinase-MB: stroke;, myocardial injury;, stroke volume.en_US
dc.identifier.doi10.1620/tjem.205.93
dc.identifier.endpage101en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue2en_US
dc.identifier.pmid15673967
dc.identifier.scopus2-s2.0-13944268366
dc.identifier.scopusqualityQ1
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.205.93
dc.identifier.urihttps://hdl.handle.net/11468/18667
dc.identifier.volume205en_US
dc.identifier.wosWOS:000226498600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal of Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiac Troponin Ten_US
dc.subjectCreatine Kinase-Mben_US
dc.subjectStrokeen_US
dc.subjectMyocardial Injuryen_US
dc.subjectStroke Volumeen_US
dc.titleSerum cardiac troponin T levels as an indicator of myocardial injury in ischemic and hemorrhagic stroke patientsen_US
dc.titleSerum cardiac troponin T levels as an indicator of myocardial injury in ischemic and hemorrhagic stroke patients
dc.typeArticleen_US

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