Effects of oral fat and glucose tolerance test on serum lipid profile, apolipoprotein, and CRP concentration, and insulin resistance in patients with polycystic ovary syndrome

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dc.contributor.authorBahçeci, Mithat
dc.contributor.authorAydemir, Mehmet
dc.contributor.authorTuzcu, Alpaslan Kemal
dc.contributor.orcid0000-0002-1814-9773
dc.date.accessioned2024-04-24T17:56:07Z
dc.date.available2024-04-24T17:56:07Z
dc.date.issued2007
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractObjective: To evaluate serum lipid responses and insulin resistance to a high-fat content meal in patients with polycystic ovary syndrome (PCOS). Design: Controlled clinical study. Setting: Healthy volunteers and patients with PCOS in clincial research. Patient(s): Twenty women with PCOS (22.7 ± 4 years, body mass index [BMI]: 23.5 ± 2.6 kg/m2) and 20 age- and BMI-matched control women (22.8 ± 4, BMI: 23.1 ± 3.1 kg/m2) were included in the study. Waist circumference, BMI, fat mass, fat percent, and fat-free mass were measured. Intervention(s): A standard oral glucose tolerance test (75 g of glucose, 2 hours) was performed, and the area under the curve-glucose (AUCglu) and homeostasis model assessment of insulin resistance (HOMA-IR) were used for insulin resistance. An oral fat tolerance test (OFTT) with 500 mL standard fat meal (1493 kcal) was performed. With OFTT, both timely (at 0, second, fourth, sixth, and eighth hours) and AUCtriglyceride, AUCtotal-cholesterol, AUCVLDL-cholesterol, AUCHDL-cholesterol, AUCLDL-cholesterol, AUCinsulin, AUCglucose, AUChs-CRP, AUCLP(a), AUCApoA1, and AUCApoB responses were evaluated. Main Outcome Measure(s): Plasma lipid, insulin, and C-reactive protein levels. Result(s): Waist circumference, fat percent, and HOMA-IR values of PCOS patients were higher than those of control subjects. AUCglu values were also higher in patients with PCOS. After OFTT, AUCtriglyceride, AUCtotal cholesterol, and AUCVLDL values were higher in patients with PCOS. Conclusion(s): Patients with PCOS have insulin resistance and prolonged lipid response to OFTT. These exaggerated responses may cause early atherogenesis in these patients.en_US
dc.identifier.citationBahçeci, M., Aydemir, M. ve Tuzcu, A. K. (2007). Effects of oral fat and glucose tolerance test on serum lipid profile, apolipoprotein, and CRP concentration, and insulin resistance in patients with polycystic ovary syndrome. Fertility and Sterility, 87(6), 1363-1368.
dc.identifier.doi10.1016/j.fertnstert.2006.11.031
dc.identifier.endpage1368en_US
dc.identifier.issn0015-0282
dc.identifier.issue6en_US
dc.identifier.pmid17362944
dc.identifier.scopus2-s2.0-34249700321
dc.identifier.scopusqualityQ1
dc.identifier.startpage1363en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2006.11.031
dc.identifier.urihttps://hdl.handle.net/11468/23306
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0015028206045134?via%3Dihub
dc.identifier.volume87en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBahçeci, Mithat
dc.institutionauthorTuzcu, Alpaslan Kemal
dc.language.isoenen_US
dc.relation.ispartofFertility and Sterility
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApolipoproteinen_US
dc.subjectArea under curveen_US
dc.subjectCholesterolen_US
dc.subjectİnsulin resistanceen_US
dc.subjectOral fat tolerance testen_US
dc.subjectTriglyceridesen_US
dc.titleEffects of oral fat and glucose tolerance test on serum lipid profile, apolipoprotein, and CRP concentration, and insulin resistance in patients with polycystic ovary syndromeen_US
dc.titleEffects of oral fat and glucose tolerance test on serum lipid profile, apolipoprotein, and CRP concentration, and insulin resistance in patients with polycystic ovary syndrome
dc.typeArticleen_US

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