Effects of oral fat and glucose tolerance test on serum lipid profile, apolipoprotein, and CRP concentration, and insulin resistance in patients with polycystic ovary syndrome

[ X ]

Tarih

2007

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Objective: To evaluate serum lipid responses and insulin resistance to a high-fat content meal in patients with polycystic ovary syndrome (PCOS). Design: Controlled clinical study. Setting: Healthy volunteers and patients with PCOS in clincial research. Patient(s): Twenty women with PCOS (22.7 ± 4 years, body mass index [BMI]: 23.5 ± 2.6 kg/m2) and 20 age- and BMI-matched control women (22.8 ± 4, BMI: 23.1 ± 3.1 kg/m2) were included in the study. Waist circumference, BMI, fat mass, fat percent, and fat-free mass were measured. Intervention(s): A standard oral glucose tolerance test (75 g of glucose, 2 hours) was performed, and the area under the curve-glucose (AUCglu) and homeostasis model assessment of insulin resistance (HOMA-IR) were used for insulin resistance. An oral fat tolerance test (OFTT) with 500 mL standard fat meal (1493 kcal) was performed. With OFTT, both timely (at 0, second, fourth, sixth, and eighth hours) and AUCtriglyceride, AUCtotal-cholesterol, AUCVLDL-cholesterol, AUCHDL-cholesterol, AUCLDL-cholesterol, AUCinsulin, AUCglucose, AUChs-CRP, AUCLP(a), AUCApoA1, and AUCApoB responses were evaluated. Main Outcome Measure(s): Plasma lipid, insulin, and C-reactive protein levels. Result(s): Waist circumference, fat percent, and HOMA-IR values of PCOS patients were higher than those of control subjects. AUCglu values were also higher in patients with PCOS. After OFTT, AUCtriglyceride, AUCtotal cholesterol, and AUCVLDL values were higher in patients with PCOS. Conclusion(s): Patients with PCOS have insulin resistance and prolonged lipid response to OFTT. These exaggerated responses may cause early atherogenesis in these patients.

Açıklama

Anahtar Kelimeler

Apolipoprotein, Area under curve, Cholesterol, İnsulin resistance, Oral fat tolerance test, Triglycerides

Kaynak

Fertility and Sterility

WoS Q Değeri

Scopus Q Değeri

Q1

Cilt

87

Sayı

6

Künye

Bahçeci, M., Aydemir, M. ve Tuzcu, A. K. (2007). Effects of oral fat and glucose tolerance test on serum lipid profile, apolipoprotein, and CRP concentration, and insulin resistance in patients with polycystic ovary syndrome. Fertility and Sterility, 87(6), 1363-1368.