One year results of anti-VEGF treatment in pigment epithelial detachment secondary to macular degeneration
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Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Consel Brasil Oftalmologia
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: Pigment epithelial detachment (PED) may be seen in all stages of age-related macular degeneration (ARMD) and may lead to poor prognosis. In this study, we retrospectively examined the effect of anti-VEGF treatments in ARMD patients with vascularized PED. Methods: Medical records of 15 patients with PED secondary to ARMD were re--viewed retrospectively. The diagnosis of PED was made with fundoscopy, fundus fluorescein angiography and optical coherence tomography. Patients were treated with intravitreal ranibizumab or/and bevacizumab and followed up for a minimum of one year. PED height and best corrected visual acuity (BCVA) was obtained before the first intravitreal anti-VEGF injection and again at the 1st, 3rd, 6th and 12th month after the injection. Results: The mean baseline BCVA was 0.71 +/- 0.48 logarithm of the minimal angle of resolution (logMAR) unit and the mean baseline PED height was 361 +/- 153 mu. The mean injection count per eye was 3.9 +/- 2.9. There was a significant reduce in mean PED height (247 +/- 177 mu) also in 2 eyes PED completely resolved at the end of the follow up period. The mean BCVA at 12th month (0,69 +/- 0,37) were not different from the baseline record. Conclusions: This retrospective case series showed that intravitreal anti-VEGF therapy preserved vision and reduced PED height in PED patients in a one-year follow-up period.
Açıklama
Anahtar Kelimeler
Vascular Endothelial Growth Factor A/Antagonists & Inhibitors, Retinal Pigment Epithelium/Pathology, Retinal Detachment, Macular Degeneration/Drug Therapy, Aged
Kaynak
Arquivos Brasileiros De Oftalmologia
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
76
Sayı
4
