Expression of vascular endothelial growth factor receptors and their ligands in rat uterus during the postpartum involution period

Basit Öğe Kaydı
dc.contributor.authorSagsoz, H.
dc.contributor.authorLiman, N.
dc.contributor.authorAlan, E.
dc.date.accessioned2024-04-24T17:20:31Z
dc.date.available2024-04-24T17:20:31Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractVascular endothelial growth factor (VEGF) and its specific receptors, FLt1/fms, Flk1/KDR and FLt4, play important roles in vasculogenesis, and physiological and pathological angiogenesis. Whether angiogenic growth factors are involved in regulating angiogenic processes during the postpartum involution period (PP) of the rat uterus is unknown. We used immunohistochemistry to analyze the expression levels of VEGF, the fms-like tyrosine kinase 1 (FLt1/fms), the kinase insert domain-containing region 1 (Flk1/KDR), Fms-related tyrosine kinase 4 (FLt4) and vascular endothelial growth inhibitor (VEGI) in the rat uterus during the days 1, 3, 5, 10 and 15 of the PP to determine the temporal and spatial expressions of VEGF and its receptors during the PP. Throughout the PP, cytoplasmic and membrane staining of VEGI, VEGF and their receptors were observed in the lumens, crypts and glandular epithelial cells as well as in connective tissue and vascular endothelial and smooth muscle cells in the endometrium. We found that the intensity of the immunoreactions in the endometrium varied with the morphological changes that occurred during involution. Immunoreactions for VEGI, VEGF and their receptor, Flk1/KDR, in the luminal epithelial cells were stronger than those in the glandular epithelial and stromal cells, particularly during PP 1, 3 and 5, which suggests that these peptides may contribute to re-epithelialization of the endometrium. On the other hand, Flt1/fms immunoreactivity was strong mainly in the stromal cells during the PP. The presence of VEGF and its receptors (FLt1/fms, Flk1/KDR, FLt4) in the stromal cells and blood vessels during the PP suggests that they may contribute to regulating stromal repair and angiogenesis in the involuting uterus of the rat.en_US
dc.identifier.doi10.3109/10520295.2015.1007482
dc.identifier.endpage374en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5en_US
dc.identifier.pmid25801298
dc.identifier.scopus2-s2.0-84931090964
dc.identifier.scopusqualityQ2
dc.identifier.startpage361en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2015.1007482
dc.identifier.urihttps://hdl.handle.net/11468/19100
dc.identifier.volume90en_US
dc.identifier.wosWOS:000361304600006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometriumen_US
dc.subjectInvolutionen_US
dc.subjectPostpartum Perioden_US
dc.subjectRaten_US
dc.subjectUterusen_US
dc.subjectVegfen_US
dc.subjectVegien_US
dc.titleExpression of vascular endothelial growth factor receptors and their ligands in rat uterus during the postpartum involution perioden_US
dc.titleExpression of vascular endothelial growth factor receptors and their ligands in rat uterus during the postpartum involution period
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu