Evaluation of the effects of different hemostatic agent applications on mental nerve

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dc.authorid0000-0002-7385-3130en_US
dc.authorid0000-0001-8349-3506en_US
dc.authorid0000-0003-3661-2378en_US
dc.contributor.authorAdak, Berat Metin
dc.contributor.authorLaçin, Nihat
dc.contributor.authorŞimşek, Fatma
dc.contributor.authorUysal, Ersin
dc.contributor.authorSoylu, Fahri Emrah
dc.contributor.authorÖzkan, İrem
dc.date.accessioned2024-03-04T10:52:19Z
dc.date.available2024-03-04T10:52:19Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Diyarbakır Teknik Bilimler Meslek Yüksekokulu, Bilgisayar Teknolojileri Bölümüen_US
dc.description.abstractPurpose: Evaluating the effect of ABS (Ankaferd Blood Stopper®), Tranexamic Acid (Transamin®) and Thrombin-Containing Hemostatic Matrix (Floseal®) on the mental nerve of rats by using histopathologic and immunohistochemical analyses. Materials and methods: 40 Wistar Albino rats were used. Rats were randomly selected into 4 groups as Control (G1), ABS (G2), Tranexamic Acid (G3) and Thrombin-Containing Hemostatic Matrix (G4). In the control group G1, the left mental nerve was exposed and 0.3 ml of sterile saline was applied for 5 min, then closed with suture. In the other three groups, the left mental nerve was exposed and 0.3 ml ABS, Tranexamic Acid and Floseal was applied to groups, respectively. After 5 min, wounds were closed with suture. Immunohistochemical and histopathologic examinations were performed on mental nerves after 28 days. Results: The total histopathologic and immunohistochemical semiquantitative scores were significantly higher in ABS (G2) compared to Control (G1), Tranexamic Acid (G3) and Thrombin-Containing Hemostatic Matrix (G4) (P < 0.05). Myelin thickness were significantly lower in G2 compared to G1, G2 and G3 (P < 0.05). G3 has the most reliable results compared to G2 and G4 (P < 0.05). Conclusion: The study results suggest that ABS has neurotoxic effects and should not be used close to the nerve, and thrombin-containing hemostatic matrix should be used carefully. Tranexamic acid, on the other hand, was found to be the most reliable hemostatic agent for use in close proximity to neural tissues. Further studies are required to determine the efficacy of the hemostatic agents on peripheral nerve degeneration.en_US
dc.identifier.citationAdak, B. M., Laçin, N., Şimşek, F., Uysal, F., Soylu, F. E., Özkan, İ. ve diğerleri. (2022). Evaluation of the effects of different hemostatic agent applications on mental nerve. European Archives of Oto-Rhino-Laryngology, 279(11), 5355-5362.en_US
dc.identifier.doi10.1007/s00405-022-07434-3
dc.identifier.endpage5362en_US
dc.identifier.issn0937-4477
dc.identifier.issue11en_US
dc.identifier.pmid35767059
dc.identifier.scopus2-s2.0-85133203617
dc.identifier.scopusqualityQ1
dc.identifier.startpage5355en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s00405-022-07434-3
dc.identifier.urihttps://hdl.handle.net/11468/13482
dc.identifier.volume279en_US
dc.identifier.wosWOS:000818621200005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUysal, Ersin
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHemostatic agentsen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMental nerveen_US
dc.subjectNeural degenerationen_US
dc.titleEvaluation of the effects of different hemostatic agent applications on mental nerveen_US
dc.titleEvaluation of the effects of different hemostatic agent applications on mental nerve
dc.typeArticleen_US

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