The Levels of Cortisol and Oxidative Stress and DNA Damage in Child and Adolescent Victims of Sexual Abuse with or without Post-Traumatic Stress Disorder

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dc.contributor.authorSimsek, Seref
dc.contributor.authorYuksel, Tugba
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorUysal, Cem
dc.contributor.authorAktas, Huseyin
dc.date.accessioned2024-04-24T17:24:34Z
dc.date.available2024-04-24T17:24:34Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective The aim of this study was to investigate whether cortisol and oxidative stress levels and DNA damage differ between individuals who developed PTSD or not following a sexual trauma. Methods The study included 61 children aged between 5 and 17 years who sustained sexual abuse (M/F: 18/43). The patients were divided into two groups: patients with PTSD and patients without PTSD based, based on the results of a structured psychiatric interview (K-SADS-PL and CAPS-CA). Cortisol, glutathione peroxidase (GPx), superoxide dismutase (SOD), coenzyme Q 8-Hydroxy-2-Deoxyguanosine (8-OHdG) were all evaluated by the ELISA method. Results Our evaluation revealed a diagnosis of PTSD in 51% (n=31) of victims. There was no significant difference between the groups with or without PTSD in terms of cortisol, GPx, SOD, coenzyme Q, and 8-OHdG levels. There was no correlation between CAPS scores and GPx, SOD, coenzyme Q, and 8-OHdG levels between patients with or without PTSD. In patients with PTSD, both cortisol and 8-OHdG levels decreased with increasing time after trauma, and there was no significant correlation with cortisol and 8-OHdG levels in patients without PTSD. Conclusion Although the present study did not find any difference between the groups in terms of 8-OHdG concentrations, the decreases in both cortisol and 8-OHdG levels with increasing time after trauma is considered to indicate a relationship between cortisol and DNA damage.en_US
dc.identifier.doi10.4306/pi.2016.13.6.616
dc.identifier.endpage621en_US
dc.identifier.issn1738-3684
dc.identifier.issn1976-3026
dc.identifier.issue6en_US
dc.identifier.pmid27909452
dc.identifier.scopus2-s2.0-85006277743
dc.identifier.scopusqualityQ2
dc.identifier.startpage616en_US
dc.identifier.urihttps://doi.org/10.4306/pi.2016.13.6.616
dc.identifier.urihttps://hdl.handle.net/11468/19737
dc.identifier.volume13en_US
dc.identifier.wosWOS:000388782600006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKorean Neuropsychiatric Assocen_US
dc.relation.ispartofPsychiatry Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCortisolen_US
dc.subjectDna Damageen_US
dc.subjectOxidative Stressen_US
dc.subjectPtsden_US
dc.subjectSexual Abuseen_US
dc.subjectTraumaen_US
dc.titleThe Levels of Cortisol and Oxidative Stress and DNA Damage in Child and Adolescent Victims of Sexual Abuse with or without Post-Traumatic Stress Disorderen_US
dc.titleThe Levels of Cortisol and Oxidative Stress and DNA Damage in Child and Adolescent Victims of Sexual Abuse with or without Post-Traumatic Stress Disorder
dc.typeArticleen_US

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