Penetrating Keratoplasty in Congenital Hereditary Endothelial Dystrophy

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dc.contributor.authorOzdemir, Burak
dc.contributor.authorKubaloglu, Anil
dc.contributor.authorKoytak, Arif
dc.contributor.authorCoskun, Erol
dc.contributor.authorCinar, Yasin
dc.contributor.authorSari, Esin Sogutlu
dc.contributor.authorOzerturk, Yusuf
dc.date.accessioned2024-04-24T17:08:17Z
dc.date.available2024-04-24T17:08:17Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: To compare the results of penetrating keratoplasty (PK) in a series of congenital hereditary endothelial dystrophy (CHED) patients operated at amblyogenic years and at later ages. Methods: Records of 65 eyes of 35 CHED patients who underwent PK were reviewed retrospectively. Visual results and graft clarity rates were compared between patients operated after (group 1) and before (group 2) 12 years of age. Results were also compared between eyes with and without nystagmus. Results: Group 1 consisted of 47 eyes (24 patients), whereas group 2 consisted of 18 eyes (11 patients). Thirteen patients (54%) in group 1 and 10 patients (91%) in group 2 had nystagmus. Mean ages at surgery were 26.4 and 7.6 years in group 1 and group 2, respectively. Mean follow-up period was 101.0 months in group 1 and 59.7 months in group 2. Group 1 cases had better graft clarity rates than group 2 cases (P = 0.023). Postoperative best-corrected visual acuities (BCVAs) were 20/80 or better in 39 eyes of group 1 (83%) and in 5 eyes of group 2 (28%). Visual outcomes were found significantly better in group 1 cases (P < 0.001). In group 1, 76% of eyes with nystagmus and 91% of eyes without nystagmus had BCVAs of 20/80 or better. In group 1, both preoperative and postoperative BCVAs were found significantly better in eyes without nystagmus (P < 0.001 and P = 0.002, respectively). Conclusions: Delayed keratoplasty seems to offer better graft outcomes and visual prognosis to CHED patients, even in the presence of nystagmus.en_US
dc.identifier.doi10.1097/ICO.0b013e31823d03af
dc.identifier.endpage365en_US
dc.identifier.issn0277-3740
dc.identifier.issue4en_US
dc.identifier.pmid22240922
dc.identifier.scopus2-s2.0-84858701886
dc.identifier.scopusqualityQ1
dc.identifier.startpage359en_US
dc.identifier.urihttps://doi.org/10.1097/ICO.0b013e31823d03af
dc.identifier.urihttps://hdl.handle.net/11468/17283
dc.identifier.volume31en_US
dc.identifier.wosWOS:000301354500004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCornea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCongenital Hereditary Endothelial Dystrophyen_US
dc.subjectPenetrating Keratoplastyen_US
dc.subjectGraft Survivalen_US
dc.titlePenetrating Keratoplasty in Congenital Hereditary Endothelial Dystrophyen_US
dc.titlePenetrating Keratoplasty in Congenital Hereditary Endothelial Dystrophy
dc.typeArticleen_US

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