Evaluation of QT dispersion and Tp-e interval in children with subclinical hypothyroidism

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dc.authorid0000-0001-8780-8122en_US
dc.authorid0000-0002-5299-9480en_US
dc.authorid0000-0002-9809-0977en_US
dc.authorid0000-0003-1587-9559en_US
dc.contributor.authorAkın, Alper
dc.contributor.authorÜnal, Edip
dc.contributor.authorYıldırım, Ruken
dc.contributor.authorTüre, Mehmet
dc.contributor.authorBalık, Hasan
dc.contributor.authorHaspolat, Yusuf Kenan
dc.date.accessioned2021-12-01T06:25:29Z
dc.date.available2021-12-01T06:25:29Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground: Studies on adults have shown increased dispersion of QT and corrected QT (QTc), peak-to-end interval of the T wave (Tp-e), Tp-e/QT ratio, and Tp-e/QTc ratio in subclinical hypothyroidism (SH), but there have been no pediatric studies. Materials and methods: A total of 40 SH patients were compared with 40 healthy children in respect to serum thyroid-stimulating hormone (TSH), serum-free level of triiodothyronine, and free level of thyroxine (fT4). SH diagnosis was accepted as TSH above the laboratory accepted upper limit (>4.2 mU/L) and normal fT4 values. The patient and control group data were compared by calculating the QT interval, QTc, QT dispersion (QTd), QTc dispersion (QTcd), Tp-e, Tp-e/QT ratio, and Tp-e/QTc ratio on 12-lead surface electrocardiogram. Results: The mean age was 7.91 ± 3.6 years in the SH group and 8.8 ± 2.4 years in the control group. In the SH group, the minimum QT (QTmin) was determined to be statistically significantly lower (P < 0.001) and maximum QT (QTmax), QTd, QTcd, Tp-e, Tp-e/QT ratio, and Tp-e/QTc ratio were statistically significantly higher (P = 0.028, P < 0.001, P = 0.003, P < 0.001, P = 0.001, P < 0.001, respectively). A positive correlation was determined between TSH and QTmax (r: +0.331, P = 0.037). Conclusions: The current study is the first to have shown significantly increased QTd, QTcd, Tp-e, Tp-e/QT ratio, and Tp-e/QTc ratio in children diagnosed with SH. A positive correlation was determined between TSH and maximum QT values, Tp-e, Tp-e/QT ratio, and Tp-e/QTc ratio. These results suggest the need to further assess the long-term risks of prolonged QT dispersion in the setting of subclinical hypothyroidism.en_US
dc.identifier.citationAkın, A., Ünal, E., Yıldırım, R., Türe, M., Balık, H., Haspolat, Y. K. ve diğerleri. (2018). Evaluation of QT dispersion and Tp-e interval in children with subclinical hypothyroidism. Pacing and Clinical Electrophysiology, 41(4), 372-375.en_US
dc.identifier.doi10.1111/pace.13286
dc.identifier.endpage375en_US
dc.identifier.issue4en_US
dc.identifier.pmid29369370
dc.identifier.scopus2-s2.0-85042562214
dc.identifier.scopusqualityN/A
dc.identifier.startpage372en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/29369370/
dc.identifier.urihttps://hdl.handle.net/11468/8342
dc.identifier.volume41en_US
dc.identifier.wosWOS:000430127800007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkın, Alper
dc.institutionauthorÜnal, Edip
dc.institutionauthorYıldırım, Ruken
dc.institutionauthorTüre, Mehmet
dc.institutionauthorBalık, Hasan
dc.institutionauthorHaspolat, Yusuf Kenan
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPacing and Clinical Electrophysiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectQT dispersionen_US
dc.subjectChildrenen_US
dc.subjectSubclinical hypothyroidismen_US
dc.subjectVentricular repolarizationen_US
dc.titleEvaluation of QT dispersion and Tp-e interval in children with subclinical hypothyroidismen_US
dc.titleEvaluation of QT dispersion and Tp-e interval in children with subclinical hypothyroidism
dc.typeArticleen_US

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