Oxidative Status and Acute Phase Reactants in Patients with Environmental Asbestos Exposure and Mesothelioma

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dc.contributor.authorSezgi, Cengizhan
dc.contributor.authorTaylan, Mahsuk
dc.contributor.authorSen, Hadice Selimoglu
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorKaya, Halide
dc.contributor.authorAbakay, Ozlem
dc.contributor.authorAbakay, Abdurrahman
dc.date.accessioned2024-04-24T17:12:13Z
dc.date.available2024-04-24T17:12:13Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Objectives. The aim of this study was to investigate inflammatory indicators and oxidative status in patients with asbestos exposure with and without mesothelioma and to compare results with data from healthy subjects. Methods. Eighty people with exposure to environmental asbestos and without any disease, 46 mesothelioma patients, and a control group of 50 people without exposure to environmental asbestos were enrolled in this prospective study. Serum total oxidant level (TOL), total antioxidant capacity (TAC), and oxidative stress index (OSI), CRP, transferrin, ceruloplasmin, alpha-1 antitrypsin, ferritin, and copper levels were measured. Results. Mesothelioma group exhibited higher TOL, OSI, alpha 1-antitrypsin, ferritin and copper levels as compared to the other groups (P < 0.001, P = 0.007, P < 0.0001, P < 0.001, and P < 0.001, resp.). Transferrin was lower in the mesothelioma group than in the other two groups (P < 0.001). The asbestos group had higher TOL, TAC, alpha 1-antitrypsin, and transferrin levels (P < 0.001, P < 0.001, P < 0.001, and P < 0.001, resp.), as well as lower OSI and ferritin levels as compared to the control group (P < 0.001 and P < 0.001). Conclusions. We believe that elevated acute phase reactants and oxidative stress markers (TOL and OSI) in the mesothelioma group can be used as predictive markers for the development of asbestos-related malignancy.en_US
dc.description.sponsorshipDicle University DUBAPen_US
dc.description.sponsorshipThe authors declare that this paper has not been published anywhere previously and is not simultaneously being considered for any other publication. They are grateful to Dicle University DUBAP for their sponsorship about English editing of this paper. This study has not been published or submitted elsewhere and there is no conflict of interests for this study.en_US
dc.identifier.doi10.1155/2014/902748
dc.identifier.issn1537-744X
dc.identifier.pmid24592197
dc.identifier.scopus2-s2.0-84893830809
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/2014/902748
dc.identifier.urihttps://hdl.handle.net/11468/17895
dc.identifier.wosWOS:000330739800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.ispartofScientific World Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleOxidative Status and Acute Phase Reactants in Patients with Environmental Asbestos Exposure and Mesotheliomaen_US
dc.titleOxidative Status and Acute Phase Reactants in Patients with Environmental Asbestos Exposure and Mesothelioma
dc.typeArticleen_US

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