Voltammetric studies and spectroscopic investigations of the interaction of an anticancer drug bevacizumab-DNA and analytical applications of disposable pencil graphite sensor

Basit Öğe Kaydı
dc.authorid0000-0002-0868-2769en_US
dc.authorid0000-0001-5792-419Xen_US
dc.contributor.authorAslan, Mehmet
dc.contributor.authorAydın, Fırat
dc.contributor.authorLevent, Abdulkadir
dc.date.accessioned2023-08-15T11:46:07Z
dc.date.available2023-08-15T11:46:07Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.description.abstractA sensitive, simple, fast electrochemical biosensor for the DNA interaction of bevacizumab (BEVA), which is used as a targeted drug in cancer treatment, was developed using the differential pulse voltammetry (DPV) technique with pencil graphite electrode (PGE). In the work, PGE was electrochemically activated in a supporting electrolyte medium of +1.4 V/60 s (PBS pH 3.0). Surface characterization of PGE was carried out by SEM, EDX, EIS, and CV techniques. Determination and electrochemical properties of BEVA were examined with CV and DPV techniques. BEVA gave a distinct analytical signal on the PGE surface at a potential of +0.90 V (vs. Ag/AgCl). In the procedure proposed in this study, BEVA gave a linear response on PGE in PBS (pH 3.0 containing 0.02 M NaCl) (0.1 mg mL−1 – 0.7 mg mL−1) with LOD and LOQ values of 0.026 mg mL−1 and 0.086 μg mL−1, respectively. BEVA was reacted with 20 μg mL−1 DNA in PBS for 150 s and analytical peak signals for adenine and guanine bases were evaluated. The interaction between BEVA-DNA was supported by UV–Vis. Absorption spectrometry and the binding constant was determined as 7.3 × 104.en_US
dc.identifier.citationAslan, M., Aydın, F. ve Levent, A. (2023). Voltammetric studies and spectroscopic investigations of the interaction of an anticancer drug bevacizumab-DNA and analytical applications of disposable pencil graphite sensor. Talanta, (265), 1-8.en_US
dc.identifier.doi10.1016/j.talanta.2023.124893
dc.identifier.endpage8en_US
dc.identifier.issn0039-9140
dc.identifier.issue265en_US
dc.identifier.pmid37437394
dc.identifier.scopus2-s2.0-85164225669
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0039914023006446?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/12482
dc.identifier.wosWOS:001038222300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAslan, Mehmet
dc.institutionauthorAydın, Fırat
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofTalanta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKeywordsen_US
dc.subjectBevacizumab DNAen_US
dc.subjectInteraction PGEen_US
dc.subjectVoltammetricen_US
dc.subjectSpectrometricen_US
dc.titleVoltammetric studies and spectroscopic investigations of the interaction of an anticancer drug bevacizumab-DNA and analytical applications of disposable pencil graphite sensoren_US
dc.titleVoltammetric studies and spectroscopic investigations of the interaction of an anticancer drug bevacizumab-DNA and analytical applications of disposable pencil graphite sensor
dc.typeArticleen_US

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