Left ventricular global longitudinal strain can detect subclinical left ventricular systolic dysfunction in adult patients with primary nephrotic syndrome

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dc.contributor.authorCap, Nese Kanbal
dc.contributor.authorAydin, Emre
dc.contributor.authorKadiroglu, Ali Kemal
dc.contributor.authorOzbek, Mehmet
dc.contributor.authorYildirim, Yasar
dc.contributor.authorYilmaz, Zulfikar
dc.contributor.authorAydin, Fatma Yilmaz
dc.date.accessioned2024-04-24T16:02:07Z
dc.date.available2024-04-24T16:02:07Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractIt has been shown that there is an increased risk of cardiovascular events such as heart failure and death in nephrotic syndrome. Left ventricle global longitudinal strain (LVGLS) is a more sensitive measure of assessing myocardial dysfunction and is more reproducible than left ventricle ejection fraction (LVEF%). LVGLS can detectsubclinical deterioration in the left ventricle early. In this study, we aimed to investigate LVGLS in Primary Nephrotic Syndrome (PNS) patients with normal LVEF%. Patients with histopathologically confirmed PNS were evaluated for this prospective single-center study. Patients with similar age and gender characteristics without nephrotic syndrome were included as the control group. LVGLS measurements were performed by 2D speckle tracking echocardiography. A total of 171 patients, 57 with PNS and 114 in the control group, were included in the study. The mean age was 38 +/- 12 years in the study population, and 95(56%) of the patients were women. LVEF% was 60.2 +/- 4.2 in the PNS group and 61.1 +/- 3.2 in the control group, and there was no significant difference between the two groups (p=0.111). LVGLS was found to be significantly lower in the PNS group (-19.3 +/- 2.3% vs.-20.8 +/- 1.5 %, p<0.001). A significant relationship was observed between PNS and LVGLS in the multivariable linear regression analysis (beta= 4.428, CI 95% =0.57?1.48, p<0.001). A significant relationship was observed between PNS and LVGLS, and LVGLS was found to be lower in PNS patients. In patients with PNS, subclinical left ventricular systolic dysfunction may be detected in the early period by measuring LVGLS.en_US
dc.identifier.doi10.1007/s10554-023-02817-x
dc.identifier.endpage1104en_US
dc.identifier.issn1569-5794
dc.identifier.issn1875-8312
dc.identifier.issue6en_US
dc.identifier.pmid36826614
dc.identifier.scopus2-s2.0-85148578413
dc.identifier.scopusqualityQ2
dc.identifier.startpage1097en_US
dc.identifier.urihttps://doi.org/10.1007/s10554-023-02817-x
dc.identifier.urihttps://hdl.handle.net/11468/14634
dc.identifier.volume39en_US
dc.identifier.wosWOS:000945393300003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Journal of Cardiovascular Imaging
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrimary Nephrotic Syndromeen_US
dc.subjectLeft Ventricle Global Longitudinal Strainen_US
dc.subjectLeft Ventricular Systolic Dysfunctionen_US
dc.titleLeft ventricular global longitudinal strain can detect subclinical left ventricular systolic dysfunction in adult patients with primary nephrotic syndromeen_US
dc.titleLeft ventricular global longitudinal strain can detect subclinical left ventricular systolic dysfunction in adult patients with primary nephrotic syndrome
dc.typeArticleen_US

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