Cortisol and Brain-Derived Neurotrophic Factor Levels Prior to Treatment in Children With Obsessive-Compulsive Disorder

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dc.contributor.authorSimsek, Seref
dc.contributor.authorGencoglan, Salih
dc.contributor.authorYuksel, Tugba
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorAlaca, Rumeysa
dc.date.accessioned2024-04-24T17:24:12Z
dc.date.available2024-04-24T17:24:12Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: In this study, we investigated serum brain-derived neurotrophic factor (BDNF), adrenocorticotropic hormone (ACTH), and cortisol levels between children with obsessive-compulsive disorder (OCD) prior to treatment and healthy controls. In addition, the study aimed to assess any correlations between OCD symptom severity and BDNF, ACTH, and cortisol levels. Methods: Twenty-nine children, aged from 7 to 17 years (male/female: 21/8) and diagnosed with OCD according to DSM-IV prior to treatment, were compared with 25 healthy control subjects (male/female: 16/9). The study was conducted between December 2012 and December 2013. The Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime Version (K-SADS-PL), Children's Yale-Brown Obsessive Compulsive Scale, and Children's Depression Inventory (CDI) were administered to the children. BDNF, ACTH, and cortisol levels were detected using a prepared kit with the enzyme-linked immunosorbent assay method. Results: BDNF, ACTH, and cortisol levels in the OCD group were significantly higher when compared with the control group (P=.02, P=.03, and P=.046, respectively). No association was detected between the severity and duration of OCD symptoms and BDNF, ACTH, and cortisol levels. CDI scores in both groups were similar. The mean (SD) duration of OCD symptoms was 17.9 (18.5) months. Conclusions: Our findings suggest that BDNF levels adaptively increase as a result of the damaging effects of the hypothalamic-pituitary-adrenal (HPA) axis hyperactivity on brain tissue in the early stages of OCD. HPA axis abnormalities and BDNF may play a role in the pathogenesis of the disease. (C) Copyright 2016 Physicians Postgraduate Press, Inc.en_US
dc.identifier.doi10.4088/JCP.15m10146
dc.identifier.endpageE859en_US
dc.identifier.issn0160-6689
dc.identifier.issn1555-2101
dc.identifier.issue7en_US
dc.identifier.pmid27314567
dc.identifier.scopus2-s2.0-84980373446
dc.identifier.scopusqualityQ1
dc.identifier.startpageE855en_US
dc.identifier.urihttps://doi.org/10.4088/JCP.15m10146
dc.identifier.urihttps://hdl.handle.net/11468/19509
dc.identifier.volume77en_US
dc.identifier.wosWOS:000383795900003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPhysicians Postgraduate Pressen_US
dc.relation.ispartofJournal of Clinical Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleCortisol and Brain-Derived Neurotrophic Factor Levels Prior to Treatment in Children With Obsessive-Compulsive Disorderen_US
dc.titleCortisol and Brain-Derived Neurotrophic Factor Levels Prior to Treatment in Children With Obsessive-Compulsive Disorder
dc.typeArticleen_US

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