Malignant pleural mesothelioma caused by environmental exposure to asbestos in the southeast of Turkey

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dc.contributor.authorSenyigit, A
dc.contributor.authorBayram, H
dc.contributor.authorBabayigit, C
dc.contributor.authorTopçu, F
dc.contributor.authorNazaroglu, H
dc.contributor.authorBilici, A
dc.contributor.authorLeblebici, IH
dc.date.accessioned2024-04-24T17:12:20Z
dc.date.available2024-04-24T17:12:20Z
dc.date.issued2000
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Objectives: Malignant pleural mesothelioma (MPM) is reported to be common in the southeast of Turkey, as a result of environmental asbestos exposure. The aim of this study was to evaluate the computed tomography (CT) features of MPM in patients with a history of asbestos exposure. Methods: The CT scans of 117 patients who had a diagnosis of MPM were retrospectively evaluated. Additionally, CT findings of histologic subtypes were compared. Results: The most common CT findings included pleural effusion (n = 104, 89%), pleural thickening (n = 96, 82%), mediastinal pleural involvement (n = 77, 66%) and interlobar fissural involvement (n = 62, 53%). Histologic subtype analysis was performed in 89 patients; of these, epithelial, sarcomatous and mixed types were identified in 46, 23 and 20 patients, respectively. An analysis of CT findings demonstrated that the involvement of mediastinal pleural (91%), interlobar fissure (87%) and lung parenchyma (48%) was significantly more frequent in sarcomatous type, as compared to epithelial (61% and p < 0.01; 35 and 4%, p < 0.0001, respectively) and mixed types (65% and p < 0.05; 10% and p < 0.0001; 10% and p < 0.01, respectively). Furthermore, there was a significant correlation between pericardial involvement and chest walt involvement (r = 0.42, p < 0.05) in sarcomatous type. Similarly, lymphadenopathy and parenchymal involvement (r = 0.23, p < 0.02), pericardial and chest wall involvement (r = 0.25, p < 0.01), chest wall and interlobar fissural involvement (r = 0.25, p < 0.01) were significantly correlated, when CT findings of all histologic subtypes were combined. Conclusions:These results suggest that although CT findings of MPM vary, they may provide valuable clues to the diagnosis, at least in patients with a history of asbestos exposure. In addition, the presence of extensive lesions may suggest MPM of sarcomatous subtype. Copyright (C) 2000 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000056290
dc.identifier.endpage622en_US
dc.identifier.issn0025-7931
dc.identifier.issue6en_US
dc.identifier.pmid11124643en_US
dc.identifier.scopus2-s2.0-0034531230en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage615en_US
dc.identifier.urihttps://doi.org/10.1159/000056290
dc.identifier.urihttps://hdl.handle.net/11468/17934
dc.identifier.volume67en_US
dc.identifier.wosWOS:000166061500004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofRespirationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMesotheliomaen_US
dc.subjectComputed Tomographyen_US
dc.subjectEnvironmental Asbestos Exposureen_US
dc.titleMalignant pleural mesothelioma caused by environmental exposure to asbestos in the southeast of Turkeyen_US
dc.typeArticleen_US

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