Effect of Oral Isotretinoin Treatment on Retinal Nerve Fiber Layer Thickness

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dc.contributor.authorUcak, Haydar
dc.contributor.authorAykut, Veysel
dc.contributor.authorOzturk, Savas
dc.contributor.authorCicek, Demet
dc.contributor.authorErden, Ilker
dc.contributor.authorDemir, Betul
dc.date.accessioned2024-04-24T17:18:45Z
dc.date.available2024-04-24T17:18:45Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Oral isotretinoin treatment can cause ocular side effects. Objective: This study was performed to detect possible toxic effects of oral isotretinoin treatment on the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL). Methods: The study population consisted of 54 eyes of 27 patients with nodulocystic acne who used oral isotretinoin (Roaccutane) treatment. Macular GCL and peripapillary RNFL thickness measurements were performed using spectral domain optical coherence tomography (OCT) before and after therapy. Results: Before and after treatment, a complete ophthalmologic examination was normal in all eyes. However, posttreatment lower temporal (TL) values were significantly lower (76.80 +/- 16.31) than pretreatment TL values (84.96 +/- 24.83) (p = .02). There was no statistically significant difference in the other OCT values, upper temporal, superotemporal, superonasal, upper nasal, lower nasal, inferonasal, and inferotemporal (p = .35, p = .40, p = .56, p = .95, p = .94, p = .93, p = .61, respectively). Also, there was no statistically significant difference between the right and left eyes and between genders for all parameters (p > .05). Conclusion: The use of oral isotretinoin treatment has increased in recent years. In addition, oral isotretinoin treatment has a broad adverse effect potential on the ocular system. The measurement of RNFL thickness, especially TL thickness, by OCT may be useful for detecting the possible toxic effect of oral isotretinoin therapy on RNFL.en_US
dc.identifier.doi10.2310/7750.2013.13168
dc.identifier.endpage242en_US
dc.identifier.issn1203-4754
dc.identifier.issue4en_US
dc.identifier.pmid25008440
dc.identifier.scopus2-s2.0-84904396903
dc.identifier.scopusqualityQ2
dc.identifier.startpage236en_US
dc.identifier.urihttps://doi.org/10.2310/7750.2013.13168
dc.identifier.urihttps://hdl.handle.net/11468/18892
dc.identifier.volume18en_US
dc.identifier.wosWOS:000344132000006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherB C Decker Incen_US
dc.relation.ispartofJournal of Cutaneous Medicine and Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEffect of Oral Isotretinoin Treatment on Retinal Nerve Fiber Layer Thicknessen_US
dc.titleEffect of Oral Isotretinoin Treatment on Retinal Nerve Fiber Layer Thickness
dc.typeArticleen_US

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