Ischemic colitis after capecitabine plus cisplatin treatment in advanced gastric cancer

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dc.contributor.authorCetin, Bulent
dc.contributor.authorBuyukberber, Suleyman
dc.contributor.authorSenturk, Senem
dc.contributor.authorGuzel, Evrim
dc.contributor.authorCoskun, Ugur
dc.contributor.authorBenekli, Mustafa
dc.date.accessioned2024-04-24T16:02:21Z
dc.date.available2024-04-24T16:02:21Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractSystemic chemotherapy can be complicated by colonic toxicity, which usually determines the onset of pseudomembranous colitis and, rarely, of ischemic colitis in patients with cancer. This report describes the case of a 45-year-old man with advanced gastric cancer who developed severe ischemic colitis after chemotherapy with cisplatin and capecitabine. The patient developed symptoms of gastrointestinal toxicity with abdominal pain and bloody diarrhea. He had a normal white blood cell count throughout his illness; the assay of stool specimens for Clostridium difficile toxins and the stool cultures were both negative. An endoscopy showed a mild, transient ischemic colitis. Although cisplatin is related to severe colonic cytotoxicity, it has not been previously reported that capecitabine induces arterial thrombosis and necrosis of the gastrointestinal mucosa and inhibits angiogenesis. Pseudomembranous colitis is the most frequent complication in patients with cancer who undergo capecitabine-based chemotherapy and develop gastrointestinal toxicity. Once Clostridium difficile infection has been excluded, a diagnosis of ischemic colitis should be considered, especially in patients with cancer who have normal white blood cell counts.en_US
dc.identifier.doi10.1007/s11239-010-0525-x
dc.identifier.endpage506en_US
dc.identifier.issn0929-5305
dc.identifier.issue4en_US
dc.identifier.pmid21069429
dc.identifier.scopus2-s2.0-80052337713
dc.identifier.scopusqualityQ1
dc.identifier.startpage503en_US
dc.identifier.urihttps://doi.org/10.1007/s11239-010-0525-x
dc.identifier.urihttps://hdl.handle.net/11468/14759
dc.identifier.volume31en_US
dc.identifier.wosWOS:000290451300016
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Thrombosis and Thrombolysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChemotherapyen_US
dc.subjectAdverse Effectsen_US
dc.subjectColonic Complicationsen_US
dc.subjectIschemic Colitisen_US
dc.titleIschemic colitis after capecitabine plus cisplatin treatment in advanced gastric canceren_US
dc.titleIschemic colitis after capecitabine plus cisplatin treatment in advanced gastric cancer
dc.typeArticleen_US

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