N-acetylcysteine reduces lung reperfusion injury after deep hypothermia and total circulatory arrest

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dc.contributor.authorÇakir, Ö
dc.contributor.authorOruc, A
dc.contributor.authorKaya, S
dc.contributor.authorEren, N
dc.contributor.authorYildiz, F
dc.contributor.authorErdinc, L
dc.date.accessioned2024-04-24T17:11:29Z
dc.date.available2024-04-24T17:11:29Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: We hypothesized that the use of N-acetylcysteine would ameliorate the lung reper-fusion injury observed after deep hypothermia and total circulatory arrest (DHTSA). Methods: Experiments were carried out on 12 adult mongrel dogs of either sex weighing 25 to 30 kg. The animals were randomly divided into two groups of six animals each. All animals were cooled to an esophageal temperature of 15 degreesC during 30 minutes and underwent 60 minutes of DHTSA, followed by the reinstitution of cardiopulmonary bypass (CPB) and rewarming. Before rewarming, while 100 mL physiologic saline solution was added into the pump in group 1, 50 mg/kg N-acetylcysteine(NAC) was given in group II. Heart rate, mean arterial pressure, pulmonar arterial pressure, left atrial pressure, central venous pressure, and cardiac output were recorded. To measure lung tissue malondialdehyde (MDA), water content and polymorphonuclear leukocytes (PMNs) count, lung tissue samples were taken before CPB and after weaning CPB. In addition, alveolar-arterial oxygen difference (AaDO(2))for tissue oxygenation was calculated by obtaining arterial blood gas samples. Dynamic lung compliance (DLC) was measured before CPB and after CPB. Results: MDA levels before CPB of 44.2 +/- 3.9 nmol/g tissue rose to 76.6 +/- 5.6 nmol/g tissue after weaning CPB in group I (p = 0.004). In group II also, the MDA levels increased from 43.5 +/- 4.2 to 57.4 +/- 5.6 nmol MDA/g tissue after weaning CPB (p = 0.006). The MDA increase in group 11 after CPB was found to be significantly lower than in group I (p = 0.006). The wet-to-dry lung weight ratio in the NAC group was 5.1 +/- 0.2, significantly less than in the control group (5.9 +/- 0.3), (p = 0.004). AaDO(2) significantly increased in the group I and II (p = 0.002 and p = 0.002, respectively); this elevation in group I was significant than in group II (p = 0.044). In histopathological examination, it was observed that neutrophil counts in the lung parenchyma rose significantly after CPB in both groups (p < 0.001). The increase in group I was significantly larger than group II (p < 0.001). Conclusions: Results represented in our study indicate that addition of NAC into the pump after DHTSA can reduce lung reperfusion injury.en_US
dc.identifier.doi10.1111/j.0886-0440.2004.04059.x
dc.identifier.endpage225en_US
dc.identifier.issn0886-0440
dc.identifier.issn1540-8191
dc.identifier.issue3en_US
dc.identifier.pmid15151648en_US
dc.identifier.scopus2-s2.0-2542475125en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage221en_US
dc.identifier.urihttps://doi.org/10.1111/j.0886-0440.2004.04059.x
dc.identifier.urihttps://hdl.handle.net/11468/17554
dc.identifier.volume19en_US
dc.identifier.wosWOS:000221677500008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cardiac Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleN-acetylcysteine reduces lung reperfusion injury after deep hypothermia and total circulatory arresten_US
dc.typeArticleen_US

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