The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis

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dc.contributor.authorYildirim, Tuba Talo
dc.contributor.authorOzan, Gonca
dc.contributor.authorDundar, Serkan
dc.contributor.authorBozoglan, Alihan
dc.contributor.authorKaraman, Tahir
dc.contributor.authorDildes, Neval
dc.contributor.authorKaya, Can Ayhan
dc.date.accessioned2024-04-24T17:20:22Z
dc.date.available2024-04-24T17:20:22Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose The aim of this study is to evalute the anti-inflammatory effects of morus migra on experimentally-induced periodontitis in rats. Materials and Methods Twenty-four Wistar-albino rats were randomly divided into three groups: control group (C, n=8), experimental periodontitis (PER, n=8), experimental periodontitis and treated with Morus nigra (MN+PER, n=8) (50 mg/kg per day for 21 days). After 21 days, the rats were sacrificed, and alveolar bones were evaluated histopathologically and histometrically analyzed to obtain level of alveolar bone loss. The detection of RANKL and OPG were immunohistochemically performed. Serum and tissue levels of MMP-8 and MMP-13 were also analyzed. Results Morus nigra treatment decreased tissue MMP-8 and MMP-13 levels and there were significant differences in the case of tissue levels of MMP-8 and MMP-13 between groups PER and MN+PER (p=0.035, p=0.041). There were no significant differences among all the groups serum levels of MMP-8 and MMP-13 (p=0.067, p=0.082). In the histometric evaluation, alveolar bone loss was greater in the PER group compared to C and MN groups (p=0.035). Immuno-histochemical staining of RANKL activities were found significantly lower (p=0.037) and OPG activities were found significantly higher in MN+PER group when compared to PER group (p=0.021). Conclusion The present study reveals that systemic administration of Morus nigra significantly inhibited the regional alveolar bone resorption and contributes to periodontal healing in the rat experimental-periodontitis models.en_US
dc.description.sponsorshipFirat University Scientific Research Project Coordinatorship [DHF.15.02]en_US
dc.description.sponsorshipThis work was funded by the Firat University Scientific Research Project Coordinatorship (DHF.15.02) Elazig, Turkey.en_US
dc.identifier.doi10.26650/eor.20190021
dc.identifier.endpage105en_US
dc.identifier.issn2630-6158
dc.identifier.issn2651-2823
dc.identifier.issue3en_US
dc.identifier.pmid31579889
dc.identifier.scopus2-s2.0-85091046879
dc.identifier.scopusqualityQ3
dc.identifier.startpage99en_US
dc.identifier.urihttps://doi.org/10.26650/eor.20190021
dc.identifier.urihttps://hdl.handle.net/11468/18992
dc.identifier.volume53en_US
dc.identifier.wosWOS:000488851900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherIstanbul Univ Press, Istanbul Univ Rectorateen_US
dc.relation.ispartofEuropean Oral Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExperimental Periodontitisen_US
dc.subjectCytokinesen_US
dc.subjectMmp-8en_US
dc.subjectMmp-13en_US
dc.subjectMorus Nigraen_US
dc.titleThe effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitisen_US
dc.titleThe effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis
dc.typeArticleen_US

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