No association between catalase (CAT) gene polymorphisms and susceptibility to vitiligo in a Turkish population

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dc.contributor.authorAkbas, H.
dc.contributor.authorDertlioglu, S. B.
dc.contributor.authorDilmec, F.
dc.contributor.authorBalkan, M.
dc.date.accessioned2024-04-24T17:28:20Z
dc.date.available2024-04-24T17:28:20Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Aims. Vitiligo is an acquired hypomelanotic skin disorder resulting from the loss of functional melanocytes from the cutaneous epidermis. Low catalase (CAT) activity and Accumulation of hydrogen peroxide (H2O2) have been demonstrated in the epidermis of vitiligo patients. Some polymorphisms on catalase gene may have effect on the quantity and activity of catalase enzyme. The aim of this study was to investigate whether catalase (CAT) gene polymorphisms are associated with susceptibility to vitiligo in Turkish population. Materials and Methods. One hundred and three patients with vitiligo and one hundred and seven gender, age and ethnic matched controls were enrolled in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results. The CAT gene -89A>T (rs7943316) and 389C>T (rs769217) genotypes and allele frequencies of vitiligo patients did not differ significantly from those of healthy controls. Conclusions. We found no association between CAT gene -89A>T and 389C>T polymorphism and vitiligo susceptibility in Turkish vitiligo patients. Further studies with greater sample size should be performed to verify these results.en_US
dc.identifier.doi10.7417/CT.2013.1564
dc.identifier.endpageE177en_US
dc.identifier.issn0009-9074
dc.identifier.issue3en_US
dc.identifier.pmid23868633en_US
dc.identifier.scopus2-s2.0-84883646144en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageE173en_US
dc.identifier.urihttps://doi.org/10.7417/CT.2013.1564
dc.identifier.urihttps://hdl.handle.net/11468/20405
dc.identifier.volume164en_US
dc.identifier.wosWOS:000323910300007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSoc Editrice Univen_US
dc.relation.ispartofClinica Terapeuticaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCatalase Geneen_US
dc.subjectPcr-Rflpen_US
dc.subjectVitiligoen_US
dc.titleNo association between catalase (CAT) gene polymorphisms and susceptibility to vitiligo in a Turkish populationen_US
dc.typeArticleen_US

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