Effects of cigarette smoking on heart rate variability and plasma N-terminal pro-B-type natriuretic peptide in healthy subjects

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dc.contributor.authorAlyan, Omer
dc.contributor.authorKacmaz, Fehmi
dc.contributor.authorOzdemir, Ozcan
dc.contributor.authorMaden, Orhan
dc.contributor.authorTopaloglu, Serkan
dc.contributor.authorOzbakir, Cemal
dc.contributor.authorMetin, Fatma
dc.date.accessioned2024-04-24T17:11:37Z
dc.date.available2024-04-24T17:11:37Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Cigarette smoking increased the risk of acute cardiac events related with endothelial dysfunction and increased sympathetic activity. Impaired autonomic nervous activity is recognized as a considerable symptom of cardiac dysfunction and is strongly associated with increased risk overall mortality. Methods: A total of 75 healthy habitual smokers (40 female, 35 male, mean age 36.5 +/- 8.5 years), and 73 non-smokers subjects (45 female, 28 male, mean age 34.6 +/- 7.2 years) were studied. LF and LF/HF ratio were significantly higher in smokers than in non-smokers. On the contrary, SDNN, SDANN, RMSSD, and HF values were lower in smokers compared to those in non-smokers. Not the duration of smoking but the number of cigarettes smoked per day was correlated with the HRV parameters and NT-pro BNP. Furthermore, the average levels of NT-pro BNP were found to be positively correlated with LF, LF/HF and inversely correlated with SDNN, SDANN, RMSSD and HF. Results: As a result, smoking impaires sympathovagal balance and decreases the heart rate variability in healthy subjects. And even a one cigarette smoking leads to overt sympathetic excitation. Furthermore, smoking results in an increase in NT-proBNP levels and the changes in adrenergic nervous system and NT-proBNP levels are well correlated. Conclusion: These findings could contribute to the higher rate of cardiovascular events in smokers.en_US
dc.identifier.doi10.1111/j.1542-474X.2008.00213.x
dc.identifier.endpage144en_US
dc.identifier.issn1082-720X
dc.identifier.issn1542-474X
dc.identifier.issue2en_US
dc.identifier.pmid18426439
dc.identifier.scopus2-s2.0-42449124800
dc.identifier.scopusqualityQ2
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.1111/j.1542-474X.2008.00213.x
dc.identifier.urihttps://hdl.handle.net/11468/17634
dc.identifier.volume13en_US
dc.identifier.wosWOS:000255135500006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAnnals of Noninvasive Electrocardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectElectrophysiologyen_US
dc.subjectAutonomic Nervous System And Clinicalen_US
dc.subjectNoninvasive Techniquesen_US
dc.subjectHeart Rate Variability And Clinicalen_US
dc.titleEffects of cigarette smoking on heart rate variability and plasma N-terminal pro-B-type natriuretic peptide in healthy subjectsen_US
dc.titleEffects of cigarette smoking on heart rate variability and plasma N-terminal pro-B-type natriuretic peptide in healthy subjects
dc.typeArticleen_US

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