Does Gross Total Resection Improve Progression-Free and Overall Survival in Pediatric Intracranial Ependymomas? Single-Center Clinical Experience Of 61 Cases

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dc.contributor.authorNarin, Firat
dc.contributor.authorBahadir, Sinan
dc.contributor.authorHanalioglu, Sahin
dc.contributor.authorKarakaya, Dicle
dc.contributor.authorBasar, Ibrahim
dc.contributor.authorIsikay, Ilkay
dc.contributor.authorSoylemezoglu, Figen
dc.date.accessioned2024-04-24T16:18:37Z
dc.date.available2024-04-24T16:18:37Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To share our clinical experience of 25 years and identify prognostic factors for progression-free and overall survival in pediatric intracranial ependymomas. METHODS: In total, 61 children who were treated be-tween 1995 and 2020 in a single institution were included in the study. Medical records of the patients were retro-spectively reviewed to obtain and analyze the following data: patient age at first surgery, sex, presenting symptoms, hydrocephalus and any invasive treatment, anatomic site, extent of resection, pathologic grade, time to progression, and time to death. Progression-free and overall survival rates and affecting factors were analyzed by Kaplan-Meier method. RESULTS: Dysphagia, number of surgeries, and spinal seeding were associated with progression free and overall survival in univariate analysis. The extent of resection, World Health Organization grade, and visual problems were also associated with progression whereas sex was associated with overall survival. Cox regression identified the extent of resection and single surgery as an indepen-dent prognostic factor for progression-free survival. No independent factor was found for overall survival. CONCLUSIONS: This single center experience of 25 years confirms the beneficial effect of gross total resection on disease progression. Although spinal seeding seems to affect survival rates, greater number of cases are needed to reveal its full effect.en_US
dc.identifier.doi10.1016/j.wneu.2022.06.082
dc.identifier.endpageE478en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pmid35772712
dc.identifier.scopus2-s2.0-85134576134
dc.identifier.scopusqualityQ1
dc.identifier.startpageE469en_US
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2022.06.082
dc.identifier.urihttps://hdl.handle.net/11468/16202
dc.identifier.volume165en_US
dc.identifier.wosWOS:000864471400021
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWorld Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildhooden_US
dc.subjectEpendymomaen_US
dc.subjectIntracranialen_US
dc.subjectPrognostic Factorsen_US
dc.subjectSurvivalen_US
dc.titleDoes Gross Total Resection Improve Progression-Free and Overall Survival in Pediatric Intracranial Ependymomas? Single-Center Clinical Experience Of 61 Casesen_US
dc.titleDoes Gross Total Resection Improve Progression-Free and Overall Survival in Pediatric Intracranial Ependymomas? Single-Center Clinical Experience Of 61 Cases
dc.typeArticleen_US

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