MicroRNA dysregulation in manic and euthymic patients with bipolar disorder

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dc.contributor.authorCamkurt, Mehmet Akif
dc.contributor.authorKarababa, Ibrahim Fatih
dc.contributor.authorErdal, Mehmet Emin
dc.contributor.authorKandemir, Sultan Basmaci
dc.contributor.authorFries, Gabriel R.
dc.contributor.authorBayazit, Huseyin
dc.contributor.authorAy, Mustafa Ertan
dc.date.accessioned2024-04-24T16:14:59Z
dc.date.available2024-04-24T16:14:59Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Bipolar disorder (BPD) is a major psychiatric disorder with an unclear pathophysiology. Peripheral blood samples are easily drawn, making them are good candidates for diagnosing diseases. MicroRNAs are small non-coding RNA transcripts that regulate gene expression by binding to the 3'-UTR of mRNAs and directing their degradation. The aim of this study was to use blood plasma to investigate microRNA dysregulations in bipolar manic and euthymic patients. Subjects and Methods: Blood samples were collected from 58 patients with bipolar I disorder (19 manic, 39 euthymic) and 51 healthy controls. Results: Four microRNAs (miR-29a-3p, p= 0.035; miR-106b-5p, p= 0.014; miR-107, p= 0.011; and miR-125a-3p, p= 0.014) were upregulated in the entire bipolar group, compared to the healthy controls. Seven microRNAs (miR-9-5p, p= 0.032; miR-29a-3p, p= 0.001; miR-106a-5p, p= 0.034; miR-106b-5p, p= 0.003; miR-107, p< 0.001; miR-125a-3p, p= 0.016; and miR-125b-5p, p= 0.004) were more upregulated in bipolar manic patients compared to the healthy controls, and two microRNAs (miR-106a-5p, p= 0.013, and miR-107, p= 0.021) showed statistically significant upregulation in the manic patients compared to the euthymic patients. Conclusions: Our results showed greater miRNA dysregulation in the manic patients than in the euthymic patients. Two microRNAs could be more selective for bipolar manic episodes. Future studies should include depressive patients along with euthymic and manic patients.en_US
dc.description.sponsorshipHarran University Scientific Research Committeeen_US
dc.description.sponsorshipThis study was funded by Harran University Scientific Research Committee.en_US
dc.identifier.doi10.1016/j.jad.2019.09.060
dc.identifier.endpage90en_US
dc.identifier.issn0165-0327
dc.identifier.issn1573-2517
dc.identifier.pmid31605836en_US
dc.identifier.scopus2-s2.0-85072913109en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage84en_US
dc.identifier.urihttps://doi.org/10.1016/j.jad.2019.09.060
dc.identifier.urihttps://hdl.handle.net/11468/15570
dc.identifier.volume261en_US
dc.identifier.wosWOS:000499616400010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Affective Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlooden_US
dc.subjectMicrornaen_US
dc.subjectBipolaren_US
dc.subjectManicen_US
dc.subjectEuthymicen_US
dc.subjectBiomarkeren_US
dc.titleMicroRNA dysregulation in manic and euthymic patients with bipolar disorderen_US
dc.typeArticleen_US

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