Evaluation of cholinergic enzymes and selected biochemical parameters in the serum of patients with a diagnosis of acute subarachnoid hemorrhage

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dc.authorid0000-0001-9261-3522en_US
dc.authorid0000-0001-5786-9063en_US
dc.authorid0000-0003-0071-7434en_US
dc.authorid0000-0003-3876-8376en_US
dc.authorid0000-0001-7947-9496en_US
dc.contributor.authorAycan, Abdurrahman
dc.contributor.authorTaş, Abdurrahim
dc.contributor.authorYeltekin, Aslı Çilingir
dc.contributor.authorEl-Tekreti, Sama Amer Abbas
dc.contributor.authorArslan, Ayşe
dc.contributor.authorArslan, Mustafa
dc.contributor.authorAycan, Nur
dc.date.accessioned2024-03-06T13:16:08Z
dc.date.available2024-03-06T13:16:08Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalıen_US
dc.description.abstractBackground: Spontaneous subarachnoid hemorrhage (SAH) is the most severe form of hemorrhagic stroke and accounts for 5-7% of all strokes. Several chemical enzymes and cytokines are thought to cause reactions that may affect the mortality and morbidity of SAH patients. This study aimed to examine the possible relationships between these parameters and the occurrence of SAH and the clinical-radiological parameters in patients with acute SAH. Methods: This study evaluated 44 patients, including 20 with SAH and 24 controls. We obtained blood from the patients and control groups, which was stored in heparinized tubes and used in determining tumor necrosis factor alpha (TNF-α), brain-derived neurotrophic factor (BDNF), acetylcholinesterase (AChE), caspase-3, and butyrylcholinesterase (BChE) enzymes. Results: TNF-α, BDNF, AChE, and BChE enzyme levels were not related to the Glasgow Coma scale (GCS) score in the patient group (p > 0.05), whereas higher enzyme levels of caspase-3 were associated with lower GCS scores (p < 0.05). The difference between the control and patient groups in terms of mean TNF-α levels was statistically significant (p < 0.01). The BDNF levels were statistically insignificant in the patient groups (p > 0.05). Caspase-3, AChE, and BChE levels were significantly different between the control and patient groups (p < 0.01). Conclusions: Our results may be valuable for predicting the prognosis, diagnosis, and follow-up of patients with SAH. However, further studies are required to elucidate the relationship between the clinical and radiological results in patients with SAH and certain enzymes, cytokines, and growth factors.en_US
dc.identifier.citationAycan, A., Taş, A., Yeltekin, A. Ç., El-Tekreti, S. A. A., Arslan, A., Arslan, M. ve diğerleri. (2023). Evaluation of cholinergic enzymes and selected biochemical parameters in the serum of patients with a diagnosis of acute subarachnoid hemorrhage. Translational Neuroscience, 14(1), 1-8.en_US
dc.identifier.doi10.1515/tnsci-2022-0311
dc.identifier.endpage8en_US
dc.identifier.issn2081-3856
dc.identifier.issue1en_US
dc.identifier.pmid37873057
dc.identifier.scopus2-s2.0-85175240684
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.degruyter.com/document/doi/10.1515/tnsci-2022-0311/html
dc.identifier.urihttps://hdl.handle.net/11468/13544
dc.identifier.volume14en_US
dc.identifier.wosWOS:001087290200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTaş, Abdurrahim
dc.language.isoenen_US
dc.publisherWalter de Gruyter GmbHen_US
dc.relation.ispartofTranslational Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectBrain-derived neurotrophic factoren_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectCaspase-3en_US
dc.subjectGCSen_US
dc.subjectSubarachnoid hemorrhagicen_US
dc.subjectTumor necrosis factor alphaen_US
dc.titleEvaluation of cholinergic enzymes and selected biochemical parameters in the serum of patients with a diagnosis of acute subarachnoid hemorrhageen_US
dc.titleEvaluation of cholinergic enzymes and selected biochemical parameters in the serum of patients with a diagnosis of acute subarachnoid hemorrhage
dc.typeArticleen_US

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