Effects of statins in an indomethacin-induced gastric injury model in rats

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dc.contributor.authorOzbakis-Dengiz, Gunnur
dc.contributor.authorHekimoglu, Askin
dc.contributor.authorKandemir, Nilufer
dc.contributor.authorKurcer, Zehra
dc.date.accessioned2024-04-24T17:24:36Z
dc.date.available2024-04-24T17:24:36Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground/aims: Statins have additional pleiotropic effects beyond their lipid-lowering effects. In this study, the effects of statins were evaluated in an indomethacin-induced gastric injury model in rats. Materials and Methods: Animals were divided into eight groups. Distilled water (control group), omeprazole (30 mg / kg), atorvastatin (20 and 40 mg 1 kg), simvastatin (20 and 40 mg 1 kg), and rosuvastatin (20 and 40 mg/kg) were given orally (gavage). Thirty minutes later, indomethacin (25 mg 1 kg) was administered orally to all groups. Six hours later, the animals were sacrificed by decapitation. The mean ulcer indexes for each group were calculated, and the stomachs were evaluated histopathologically. Results: The ulcer indexes were as follows: control 1.72 +/- 0.16, omeprazole 0 +/- 0.00, and atorvastatin, simvastatin and rosuvastatin (at 20 and 40 mg/kg doses, respectively) 4.28 +/- 0.39, 4.99 +/- 0.96, 1.72 +/- 0.73, 1.90 +/- 0.48, 1.85 +/- 0.26, and 1.67 +/- 0.18. Atorvastatin significantly increased the indomethacin-induced ulcer index at both doses and the erosion score at 40 mg/kg dose. Although the 20 mg/kg dose of simvastatin inhibited mononuclear leukocyte infiltration, the 40 mg/kg dose induced hyperemia. Rosuvastatin did not decrease mononuclear leukocyte or neutrophil infiltrations at 20 mg/kg dose, and only neutrophil infiltration at the 40 mg/kg dose. Conclusions: In patients with gastric discomfort, statins must be used carefully. If statin therapy is needed, we recommend to avoid using atorvastatin and to use the other statins only in the minimum effective dose.en_US
dc.identifier.doi10.4318/tjg.2012.0393
dc.identifier.endpage462en_US
dc.identifier.issn1300-4948
dc.identifier.issn2148-5607
dc.identifier.issue5en_US
dc.identifier.pmid23161290
dc.identifier.startpage456en_US
dc.identifier.trdizinid140913
dc.identifier.urihttps://doi.org/10.4318/tjg.2012.0393
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/140913
dc.identifier.urihttps://hdl.handle.net/11468/19755
dc.identifier.volume23en_US
dc.identifier.wosWOS:000311871900005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtorvastatinen_US
dc.subjectSimvastatinen_US
dc.subjectRosuvastatinen_US
dc.subjectIndomethacinen_US
dc.subjectGastric Ulceren_US
dc.titleEffects of statins in an indomethacin-induced gastric injury model in ratsen_US
dc.titleEffects of statins in an indomethacin-induced gastric injury model in rats
dc.typeArticleen_US

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