Effect of Mobile Phone Exposure on Apoptotic Glial Cells and Status of Oxidative Stress in Rat Brain

Basit Öğe Kaydı
dc.contributor.authorDasdag, Suleyman
dc.contributor.authorAkdag, M. Zulkuf
dc.contributor.authorUlukaya, Engin
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorOcak, Ali Riza
dc.date.accessioned2024-04-24T17:20:33Z
dc.date.available2024-04-24T17:20:33Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effects of mobile phone exposure on glial cells in brain. The study carried out on 31 Wistar Albino adult male rats. The rat heads in a carousel exposed to 900MHz microwave. For the study group (n:14), rats exposed to the radiation 2 h per day (7 days in a week) for 10 months. For the sham group (n: 7), rats were placed into the carousel and the same procedure was applied except that the generator was turned off. For the cage control (n: 10), nothing applied to rats in this group. In this study, rats were euthanized after 10 months of exposure periods and brains were removed. Brain tissues were immunohistochemically stained for the active (cleaved) caspase-3, which is a well-known apoptosis marker, and p53. The expression of the proteins was evaluated by a semi-quantitative scoring system. However, total antioxidative capacity (TAC), catalase, total oxidant status (TOS), and oxidative stress index were measured in rat brain. Final score for apoptosis in the exposed group was significantly lower than the sham (p < 0.001) and the cage control groups (p < 0.01). p53 was not significantly changed by the exposure (p > 0.05). The total antioxidant capacity and catalase in the experimental group was found higher than that in the sham group (p < 0.001, p < 0.05). In terms of the TOS and oxidative stress index, there was no statistically significant difference between exposure and sham groups (p > 0.05). In conclusion, the final score for apoptosis, total antioxidant capacity and catalase in rat brain might be altered by 900MHz radiation produced by a generator to represent exposure of global systems for mobile communication (GSM) cellular phones.en_US
dc.identifier.doi10.3109/15368370903206556
dc.identifier.endpage354en_US
dc.identifier.issn1536-8378
dc.identifier.issn1536-8386
dc.identifier.issue4en_US
dc.identifier.pmid20017625
dc.identifier.scopus2-s2.0-73349090930
dc.identifier.scopusqualityQ2
dc.identifier.startpage342en_US
dc.identifier.urihttps://doi.org/10.3109/15368370903206556
dc.identifier.urihttps://hdl.handle.net/11468/19126
dc.identifier.volume28en_US
dc.identifier.wosWOS:000273536700002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofElectromagnetic Biology and Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMobile Phoneen_US
dc.subjectActive Caspase-3en_US
dc.subjectP53en_US
dc.subjectOxidative Stressen_US
dc.subjectBrainen_US
dc.subjectAntioxidanten_US
dc.titleEffect of Mobile Phone Exposure on Apoptotic Glial Cells and Status of Oxidative Stress in Rat Brainen_US
dc.titleEffect of Mobile Phone Exposure on Apoptotic Glial Cells and Status of Oxidative Stress in Rat Brain
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu