Ischaemia-reperfusion injury of the peripheral nerve: An experimental study

Basit Öğe Kaydı
dc.contributor.authorSaray, Aydın
dc.contributor.authorCan, Belgin
dc.contributor.authorAkbıyık, Filiz
dc.contributor.authorAşkari İbrahim
dc.contributor.orcid0000-0002-0469-7998
dc.date.accessioned2024-04-24T15:59:17Z
dc.date.available2024-04-24T15:59:17Z
dc.date.issued1999
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik Cerrahi Ana Bilim Dalıen_US
dc.description.abstractAlthough the neuropathology of ischaemic fibre degeneration is relatively well known, its pathogenesis is poorly understood. One of the presumed mechanisms is oxidative stress, causing the breakdown of the blood-nerve barrier (BNB) and ending in lipid peroxidation, We evaluated the effect of ischaemia and reperfusion on the sciatic-tibial nerve of the rat and investigated the biochemical, pathological, and functional evidence of BNB disruption and lipid peroxidation. The distal portion and trifurcation of the sciatic nerve were rendered ischaemic by clamping the femoral vessels for 3 h and followed by varying durations of reperfusion. Reperfusion resulted in an increase in lipid peroxidation beginning from the first hour and increasing until the seventh day, followed by a gradual decline over the following weeks, Nerve oedema and ischaemic fibre degeneration (IFD) consistently became more severe and prominent with reperfusion, indicating that oxidative stress damages the BNB and causes IFD, Results of functional testing by the sciatic function index correlated with other parameters as walking track analysis results got worse as reperfusion periods increased. impairment of walking patterns was more striking after the first day and continued up to the third week, These data indicate that severe ischaemia of the peripheral nerve results in reperfusion injury, functional impairment, and disruption of the BNB, Microvascular events, which may occur during reperfusion, may be important in amplifying the nerve fibre degeneration that initiated during ischaemia, (C) 1999 Wiley-Liss, Inc.en_US
dc.identifier.citationSaray, A., Can, B., Akbıyık, F. ve Aşkar, İ. (1999). Ischaemia-reperfusion injury of the peripheral nerve: An experimental study. Microsurgery, 19(8), 374-380.
dc.identifier.doi10.1002/(SICI)1098-2752(1999)19:8<374
dc.identifier.endpage380en_US
dc.identifier.issn0738-1085
dc.identifier.issue8en_US
dc.identifier.pmid10594912
dc.identifier.scopus2-s2.0-0033390477
dc.identifier.scopusqualityQ2
dc.identifier.startpage374en_US
dc.identifier.urihttps://doi.org/10.1002/(SICI)1098-2752(1999)19:8<374
dc.identifier.urihttps://hdl.handle.net/11468/13941
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/%28SICI%291098-2752%281999%2919%3A8%3C374%3A%3AAID-MICR5%3E3.0.CO%3B2-A
dc.identifier.volume19en_US
dc.identifier.wosWOS:000084387000005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAşkar, İbrahim
dc.language.isoenen_US
dc.publisherWiley-Lissen_US
dc.relation.ispartofMicrosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleIschaemia-reperfusion injury of the peripheral nerve: An experimental studyen_US
dc.titleIschaemia-reperfusion injury of the peripheral nerve: An experimental study
dc.typeArticleen_US

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