Investigation of the toxic effects of ropivacaine corneal endothelium by the impression cytological method

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dc.contributor.authorSoker, Sevda
dc.contributor.authorCakmak, Sevin
dc.contributor.authorOlmez, Gonul
dc.contributor.authorBuyukbayram, Huseyin
dc.contributor.authorNergiz, Yusuf
dc.date.accessioned2024-04-24T17:37:35Z
dc.date.available2024-04-24T17:37:35Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To investigate the toxic effects of ropivacaine on corneal endothelium by using the impression cytological method. Methods: The study was performed between October and December 2004 in Dicle University Hospital, Diyarbakir, Turkey. Twenty-four eyes from 12 rats were used for the research. They were divided into 4 groups, each containing 3 different ropivacaine concentrations and a control. Immediately after enucleation, the corneas were excised and the endothelium was exposed to unpreserved ropivacaine 0.01, 0.1, or 1% and balanced salt solutions (BSS) as a control (6 corneas/group) for 20 minutes. The specimens were obtained by impression cytology method and stained with periodic acid shift. Then, they were examined under light microscope. Results: Blurring at cell membrane borders, vacuolization at cell cytoplasm, hydropic degeneration and increase in toxic granulation were observed in the 1% ropivacaine group. Cytoplasmic hydropic degeneration was determined in the 0.1% ropivacaine group. Cell structures were normal and almost identical to the control group in the 0.01% ropivacaine group. Conclusion: In this study, 2 major conclusions were determined. The impression cytology method can be used in examination of corneal endothelium, and exposure of rat corneal endothelium to 0.01% ropivacaine solutions in vitro appears to be nontoxic.en_US
dc.identifier.endpage1020en_US
dc.identifier.issn0379-5284
dc.identifier.issue7en_US
dc.identifier.pmid17603702
dc.identifier.scopus2-s2.0-34548414014
dc.identifier.scopusqualityQ2
dc.identifier.startpage1018en_US
dc.identifier.urihttps://hdl.handle.net/11468/21043
dc.identifier.volume28en_US
dc.identifier.wosWOS:000248396500004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleInvestigation of the toxic effects of ropivacaine corneal endothelium by the impression cytological methoden_US
dc.titleInvestigation of the toxic effects of ropivacaine corneal endothelium by the impression cytological method
dc.typeArticleen_US

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