Brucellosis as a rare cause of granulomatous hepatitis with hepatic and bone marrow granulomas: A case report

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dc.contributor.authorYalcin, Kendal
dc.contributor.authorTuncel, Elif Tugba
dc.contributor.authorUcmak, Feyzullah
dc.contributor.authorBestas, Remzi
dc.date.accessioned2024-04-24T17:17:58Z
dc.date.available2024-04-24T17:17:58Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractBrucellosis is a zoonotic infection that may involve the liver in a variety of ways, however, data on the histopathology of liver effects in brucellosis are limited. Brucellosis is generally characterized by a high fever, joint or back pain, and hepatosplenomegaly. This report illustrates a case of granulomatous hepatitis with granulomas in the liver and bone marrow in a patient who presented with non-specific symptoms, hepatomegaly, splenomegaly, digital clubbing, and laboratory signs of intrahepatic cholestasis. Granulomas were detected in the bone marrow and hepatic specimens. The diagnosis of brucellosis was based on the isolation of Brucella mellitensis in a blood culture and serum agglutination titers of 1:640. Treatment for brucellosis led to improved laboratory and clinical findings. Brucellosis should be considered in regions where it is endemic in cases of an elevated transaminase level and related clinical findings. Brucellosis should also be considered in the differential diagnosis of intrahepatic cholestasis and/ or granulomas in hepatic and bone marrow biopsies. This case report provides valuable histopathological features and detailed information of liver involvement in a case of brucellosis.en_US
dc.identifier.doi10.14744/hf.2021.2021.0038
dc.identifier.endpage140en_US
dc.identifier.issn1307-5888
dc.identifier.issn2757-7392
dc.identifier.issue3en_US
dc.identifier.pmid35784902
dc.identifier.scopus2-s2.0-85164365120
dc.identifier.scopusqualityQ3
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.14744/hf.2021.2021.0038
dc.identifier.urihttps://hdl.handle.net/11468/18489
dc.identifier.volume2en_US
dc.identifier.wosWOS:000863551100011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofHepatology Forum
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrucellosisen_US
dc.subjectBone Marrowen_US
dc.subjectGranulomatous Diseaseen_US
dc.subjectLiveren_US
dc.titleBrucellosis as a rare cause of granulomatous hepatitis with hepatic and bone marrow granulomas: A case reporten_US
dc.titleBrucellosis as a rare cause of granulomatous hepatitis with hepatic and bone marrow granulomas: A case report
dc.typeArticleen_US

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