Investigation of the arterial intima-media thickness in Behcet's disease patients without vascular complaints

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dc.contributor.authorKankilic, Nazim
dc.contributor.authorAslan, Aydin
dc.contributor.authorKarahan, Oguz
dc.contributor.authorDemirtas, Sinan
dc.contributor.authorCaliskan, Ahmet
dc.contributor.authorYavuz, Celal
dc.date.accessioned2024-04-24T17:14:45Z
dc.date.available2024-04-24T17:14:45Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives Behcet's disease is a multisystemic, inflammatory disease. Various factors have been implicated in the disease, including genetics, infections, immunoglobulins, immune complexes, antibodies, and oxidative stress. However, the underlying etiopathogenesis remains unclear. Behcet's disease can occur with or without vascular involvement. This prospective study investigated the relationship between the intima-media thickness of the major arteries, in addition to other factors affecting the disease process, in Behcet's disease without vascular involvement. Methods Twenty-four patients (average age: 38.5010.931) without vascular involvement or any vascular complaints who were diagnosed with Behcet's disease were included in the study. Sixteen healthy subjects (average age: 39.757.793) were included as a control group. Demographic information and medical histories were recorded, and routine blood tests were performed in both groups. The intima-media thickness of the subclavian, axillary, femoral, and carotid arteries of all the participants were recorded using Doppler ultrasonography. The data were then subjected to intergroup statistical and correlation analyses. Results There were no significant differences between the arterial intima-media thickness values of the Behcet's disease patients and those of the control group (p>0.05). However, there was a significant difference between the neutrophil-lymphocyte ratio (p=0.004), low-density lipoprotein (p=0.007), and triglyceride (p=0042) levels of the two groups. Significant correlations were found between intima-media thickness and neutrophil-lymphocyte ratio levels (p=0.012) and the disease duration (p=0.030). There was also a significant correlation between the intima-media thickness of the femoral artery and disease duration (p=0.014). Conclusions The results showed that the duration of illness had a significant effect on arterial intima-media thickness in Behcet's disease. Blood neutrophil-lymphocyte ratio levels were also associated with increased intima-media thickness.en_US
dc.identifier.doi10.1177/1708538117742827
dc.identifier.endpage361en_US
dc.identifier.issn1708-5381
dc.identifier.issn1708-539X
dc.identifier.issue4en_US
dc.identifier.pmid29182089
dc.identifier.scopus2-s2.0-85041905993
dc.identifier.scopusqualityQ2
dc.identifier.startpage356en_US
dc.identifier.urihttps://doi.org/10.1177/1708538117742827
dc.identifier.urihttps://hdl.handle.net/11468/18171
dc.identifier.volume26en_US
dc.identifier.wosWOS:000438625600003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofVascular
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's Diseaseen_US
dc.subjectArterial Intima-Media Thicknessen_US
dc.subjectNeutrophil-Lymphocyte Ratioen_US
dc.subjectDuration Of Diseaseen_US
dc.titleInvestigation of the arterial intima-media thickness in Behcet's disease patients without vascular complaintsen_US
dc.titleInvestigation of the arterial intima-media thickness in Behcet's disease patients without vascular complaints
dc.typeArticleen_US

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