Prophylactic administration of silybin ameliorates L-arginine-induced acute pancreatitis

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dc.authorid0000-0002-2677-3971en_US
dc.authorid0000-0002-6536-4185en_US
dc.authorid0000-0002-3456-9217en_US
dc.authorid0000-0002-5804-7552en_US
dc.contributor.authorUçmak, Feyzullah
dc.contributor.authorEkin, Nazım
dc.contributor.authorİbiloğlu, İbrahim
dc.contributor.authorArslan, Serkan
dc.contributor.authorKaplan, İbrahim
dc.contributor.authorŞenateş, Ebubekir
dc.date.accessioned2024-04-04T06:36:23Z
dc.date.available2024-04-04T06:36:23Z
dc.date.issued2016en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractBackground: Oxidative stress have been shown to play a role in the pathogenesis of acute pancreatitis. The aim of this study was to investigate the potential effect of silybin, a potent antioxidant, on L-arginine-induced acute pancreatitis in an experimental rat model. Material/Methods: Forty female Wistar Albino rats were divided into 5 groups as follows: Group 1 (C): control group (n=8), Group 2 (SL): silybin group (n=8), Group 3 (LA): acute pancreatitis group (n=8), Group 4 (SLLA): prophylaxis group (n=8), and Group 5 (LASL): treatment group (n=8). Group C (control) received 2 intraperitoneal (i.p.) injections of physiological saline at an interval of 1 h. Group SL received only a single i.p. injection of silybin. The SLLA group received a single i.p. injection of silybin before the induction of acute pancreatitis with L-arginine, whereas the LASL group received the same injection after the induction of acute pancreatitis with L-arginine. Pancreatic tissues were histopathologically examined. Levels of amylase and oxidative stress markers (total oxidant status and total anti-oxidant status) were determined in the blood samples. Oxidative stress index was calculated. Results: In comparison to the LA, the prophylaxis and treatment groups showed significant improvements in serum oxidative stress parameters (p=0.001 and p=0.005, respectively). Histopathological analysis showed that the treatment group had significant improvements in edema scores only (p=0.006), whereas the prophylaxis group had the same improvements in inflammation and necrosis scores as well as in total scores (p=0.004, 0.006, and 0.004, respectively). Conclusions: When used for prophylactic rather than therapeutic purposes, silybin ameliorates serum oxidative stress parameters and improves histopathological results via its antioxidant and anti-inflammatory properties.en_US
dc.identifier.citationUçmak, F., Ekin, N., İbiloğlu, İ., Arslan, S., Kaplan, İ. ve Şenateş, E. (2016). Prophylactic administration of silybin ameliorates L-arginine-induced acute pancreatitis. Medical Science Monitor, 22, 3641-3646.en_US
dc.identifier.doi10.12659/MSM.898014
dc.identifier.endpage3646en_US
dc.identifier.issn1234-1010
dc.identifier.pmid27725627
dc.identifier.scopus2-s2.0-84991490788
dc.identifier.scopusqualityQ1
dc.identifier.startpage3641en_US
dc.identifier.urihttps://medscimonit.com/abstract/index/idArt/898014
dc.identifier.urihttps://hdl.handle.net/11468/13825
dc.identifier.volume22en_US
dc.identifier.wosWOS:000385134500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUçmak, Feyzullah
dc.institutionauthorİbiloğlu, İbrahim
dc.institutionauthorArslan, Serkan
dc.institutionauthorKaplan, İbrahim
dc.language.isoenen_US
dc.publisherInternational Scientific Literature Inc.en_US
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute necrotizingen_US
dc.subjectAntioxidantsen_US
dc.subjectArginineen_US
dc.subjectPancreatitisen_US
dc.subjectSilymarinen_US
dc.titleProphylactic administration of silybin ameliorates L-arginine-induced acute pancreatitisen_US
dc.titleProphylactic administration of silybin ameliorates L-arginine-induced acute pancreatitis
dc.typeArticleen_US

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