Prognostic Value of Preoperative CEA and CA 19-9 Levels in Patients with Colorectal Cancer

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dc.contributor.authorBasbug, Murat
dc.contributor.authorArikanoglu, Zulfu
dc.contributor.authorBulbuller, Nurullah
dc.contributor.authorCetinkaya, Ziya
dc.contributor.authorAygen, Erhan
dc.contributor.authorAkbulut, Sami
dc.contributor.authorSatici, Omer
dc.date.accessioned2024-04-24T17:37:51Z
dc.date.available2024-04-24T17:37:51Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractAims: This study evaluated the prognostic value of the preoperative CEA and CA 19-9 levels on the survival time and TNM staging in patients with colorectal cancer. Methodology: We retrospectively analyzed 172 patients who underwent potentially curative resection of colorectal cancer (TNM I-III) between 2002 and 2007. Clinical data were obtained from medical charts, including age, gender, tumor location, TNM stage, mortality, follow-up duration, and preoperative CEA and CA 19-9 levels. A CEA >= 5ng/mL was defined as abnormal (CEA+), while the cutoff for the CA19-9 was set at 37U/mL (CA19-9+). Patients were categorized into Groups I-IV according to the preoperative serum CEA and CA 19-9 levels [CEA/CA 19-9: (-/-), (+/-), (-/+), and (+/+)]. Results: Follow-up was longest for Group I (p<0.001). Mortality rates were higher in Groups V' (p<0.001) and II (p<0.008). On comparing patients according to CEA levels, survival was longer in the CEA-negative group (p=0.0001). On comparison according to CA 19-9 levels, survival was greater in the CA 19-9-negative group (p=0.0001). While CEA (p<0.016) and CA 19-9 (p<0.001) were independent prognostic factors according to the logistic regression analysis, TNM (p=0.002), CEA (p<0.001), and CA 19-9 (p<0.001) were prognostic factors in the ROC curve analysis. Conclusions: Colorectal cancer patients with elevated levels of both CEA and CA 19-9 have a significantly poorer prognosis than those with normal levels of these tumor markers.en_US
dc.identifier.endpage405en_US
dc.identifier.issn0172-6390
dc.identifier.issue106en_US
dc.identifier.pmid21661403
dc.identifier.scopus2-s2.0-79958152012
dc.identifier.scopusqualityN/A
dc.identifier.startpage400en_US
dc.identifier.urihttps://hdl.handle.net/11468/21212
dc.identifier.volume58en_US
dc.identifier.wosWOS:000291084600025
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherH G E Update Medical Publishing S Aen_US
dc.relation.ispartofHepato-Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColorectal Canceren_US
dc.subjectCarcinoembryonic Antigen (Cea)en_US
dc.subjectCarbohydrate Antigen 19-9 (Ca 19-9)en_US
dc.titlePrognostic Value of Preoperative CEA and CA 19-9 Levels in Patients with Colorectal Canceren_US
dc.titlePrognostic Value of Preoperative CEA and CA 19-9 Levels in Patients with Colorectal Cancer
dc.typeArticleen_US

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